外源性PS应用对早产儿先天性免疫系统的影响  

Effect of Exogenous Surfactant Therapy on the Innate Host Defense Systems

作　　者：王成祥[1] 常绍鸿[1] 

机构地区：[1]河南省新乡市中心医院儿科,453000

出　　处：《中国医疗前沿》2013年第9期71-72,共2页China Healthcare Innovation

摘　　要：目的研究外源性肺表面活性物质(pulmonary surfactant,PS)的应用对早产儿先天性免疫系统的影响。方法 2011年6月-2012年1月于本院住院应用PS治疗的早产儿共15人,测定其应用前、应用后3d血清内外周血T淋巴细胞亚群和NK细胞的活性,并以健康足月儿6名为对照组。结果早产儿应用PS前,血清CD3+、CD4+、NK细胞数量及CD4+/CD8+比值均低于对照组,差异有统计学意义;而CD8+T细胞高于对照组;早产儿应用PS后3天CD3+、CD4+、NK细胞数量及CD4+/CD8+比值均有明显升高,差异有统计学意义;CD8+T细胞减少。结论应用外源性PS可有效提高早产儿先天性免疫系统的功能。Objective To investigate the levels of T lymphocytes and NK ceils in peripheral blood of preterm infants who were treated with exogenous pulmonary surfactants（exPS）. Methods From Jun. 2011 to Jan. 2012, 15 cases of preterm infants who were treated with exPS, selected over the same period 6 cases of full-term healthy infants, peripheral blood T lymphocytes and NK ceils were detected and compared. Results The results showed that CD3＋, CD4＋, NK, and the ratio of CD4＋/CD8＋ in preterm infants than that in the control group. All of that in post- surfactant were significantly higher than that in pre-surfactant. Conclusion In preterm infants, Treatment with exPS apparently stimulated the innate host defense systems.

关 键 词：肺表面活性物质 先天性免疫系统 NK细胞 

分 类 号：R722[医药卫生—儿科]