纯镁超声微弧氧化生物涂层植入体内4周的降解行为  

Degradation Behavior of Ultrasound Micro-arc Oxidation Coating on Pure Magnesium After Implanted Four Weeks

作　　者：苗波[1] 吕岩[1] 刘苗[1] 李慕勤[2] 曲立杰[2] 

机构地区：[1]佳木斯大学附属第二医院,黑龙江佳木斯154007 [2]佳木斯大学黑龙江省高校生物医学材料重点实验室,黑龙江佳木斯154007

出　　处：《中国表面工程》2013年第3期45-50,共6页China Surface Engineering

基　　金：国家自然科学基金(31070859);黑龙江省自然科学重点基金(ZD201008)

摘　　要：研究纯镁及其超声微弧氧化生物涂层种植体植入动物股骨干内的短期降解过程。利用电化学工作站测定试样在模拟体液中极化曲线。术后4周,取兔股骨干的组织进行扫描电镜观察(SEM)及锥形束检测(CBCT)观察种植体降解状况。结果表明,纯镁与超声微弧氧化生物涂层都发生了降解,在骨组织表面及镁基体的表面几乎同时发生反应,在金属-骨界面形成紧密相邻的降解层、新生骨层,并可见少量的不连续的纤维结缔组织,超声微弧氧化镁生物涂层的腐蚀降解速率及对周围骨组织的刺激明显小于纯镁基体。纯镁基体及超声微弧氧化涂层试样周围的骨组织变化符合正常骨组织的愈合过程,超声微弧氧化生物涂层显示出更好的生物相容性及降解性。The short-term degradation process of pure magnesium and ultrasonic micro-arc oxidation biocoating implants in the femoral of animals was studied.Polarization curves in SBF were tested by the electrochemical workstation.The degradation of implants in rabbit femoral tissue was observed by SEM and the tapered beam of cone beam CT（CBCT） after four weeks.The results show that both pure magnesium and ultrasound micro-arc oxidation biocoating degradated.The bone surface and the magnesium substrate reacted at the same time.Compact metal,degradation and new bone layers on interface layer of metal and bone were formed.Small amounts of discontinuous fibrous connective tissue were observed.The degradation rate and stimulation of bone tissue to the surrounding of ultrasonic micro-arc magnesium was lower than that of pure magnesium substrate.The bone tissues changes of pure magnesium and ultrasonic micro-arc oxidation magnesium implants agreed with normal bone tissue healing process.The ultrasonic micro-arc oxidation biocoating showed better biocompatibility and degradation

关 键 词：微弧氧化生物涂层 超声 纯镁 降解性 骨生长 

分 类 号：TG174.45[金属学及工艺—金属表面处理] R318.08[金属学及工艺—金属学]