新型聚原酸酯共聚物的合成及性能研究  

Synthesis and Characterization of Poly(ortho ester)

作　　者：陶扬洋[1] 巩凯[1] 王睿[1] 唐汝培[1] 

机构地区：[1]江南大学药学院,无锡215000

出　　处：《高分子通报》2013年第6期33-38,共6页Polymer Bulletin

基　　金：国家自然科学基金资助项目(批准号:21174054;21004030);教育部新世纪优秀人才支持计划项目(批准号:NCET-11-0661);教育部第43批留学回国人员科研启动基金项目

摘　　要：以二聚甘油为原料,经过酯交换及氨基脱保护反应合成了一种两端含氨基的环状原酸酯新单体。该单体与辛二酸/十二烷二酸活性酯缩聚得到两种新的疏水性聚原酸酯共聚物POEAd-1和POEAd-2,其数均分子量分别由凝胶渗透色谱(GPC)测得为1.24×104及1.81×104,分散度(PDI)分别为1.59及1.93。热失重分析法证实POEAd-1和POEAd-2具有较高的热稳定性能,其起始降解温度分别可达198.5℃及202.5℃。溶血试验和MTT细胞毒性试验表明,POEAd-1和POEAd-2均具有良好生物相容性,作为一种潜在的生物医用材料,在药物缓控释领域将具有广阔的应用前景。A new diamine monomercontaining a built-in, stabilized ortho ester group was synthesized by diglyeerol with two steps of transesterification. Two new highly hydrophobic copolymer poly（ortho ester amide）（POEAd-1 and POEAd-2） were obtained by polycondensation ofthe monomer with suberic acid bis（N-hydroxysuccinimide ester）and dodecanedioic acid bis（N-hydroxysuccinimide ester）. The number average molecular weight of POEAd-1 and POEAd-2were determined by gel permeation chromatography （GPC） ,and calculated to be 1.24 ×10^4 and 1.81 ×10^4 with polydispersity index（PDI） of 1.59 and 1.93, respectively. Thermal stabilityof POEAd-1 and POEAd-2 via thermogravimetrie analysis （TGA） were investigated） ,the temperature of the onset 5%0 weight loss is up to 198.5℃ and 202.5℃, respectively. Hemolysis test and MTT cytotoxicity test indicate that POEAd-1 and POEAd 2 has good biocompatibility as a potential biomedical materials, can bewidely used in the field of controlled drug deliever.

关 键 词：聚原酸酯 生物医用材料 生物相容性 

分 类 号：R318.08[医药卫生—生物医学工程]