2009～2011年某省手足口病重复发病人群的特征分析  

Characters of Repeated Infection of Hand-Foot-Mouth Disease

作　　者：王铁强 帅惠萍[2] 邓爱萍[3] 方艳[3] 周荃[4] 孙立梅[3] 

机构地区：[1]广东省深圳市光明新区疾病预防控制中心,广东深圳518106 [2]中山大学公共卫生学院预防医学系,广东广州510080 [3]广东省疾病预防控制中心,广东广州510300 [4]潮州市疾病预防控制中心,广东潮州521000

出　　处：《中国医药指南》2013年第13期38-40,共3页Guide of China Medicine

摘　　要：目的了解广东省手足口病重复发病人群的比例和流行病学特征,分析重复感染的手足口病实验室诊断病例病原学特点,为研究手足口病防控措施提供信息。方法利用"中国疾病预防控制信息系统"报告的2009年1月1日至2011年12月31日手足口病病例,按姓名排序后,按总记录数平均分成10部分,随机抽取1部分作为样本,利用EXCEL2007软件按一定规则确定重复发病人群,利用SPSS13.0软件描述其流行病学特征,对其中实验室确诊病例,分析其发病前后病原学构成。结果按10%的抽样比例共获得记录59294条,扣除重卡和重复发病记录,实际发病57549人,其中2.09%(1205/57549)在1个月后至3年内重复发病,平均间隔9.8个月(1～34.5个月)。病例初次发病年龄平均1.94岁,3岁以下重复发病的儿童占总数的82.10%。在有明确实验室诊断的手足病病例中,前后两次同为CA16或EV71的各有1例。珠三角地区重复发病病例的比例为2.38%,非珠三角地区为1.45%;城市重复发病病例的比例为2.28%,农村重复发病病例的比例为1.86%。结论因手足口病由多种肠道病毒引起,有2%的人群出现再次发病,珠三角地区重复发病病例的比例高于非珠三角地区,城市重复发病病例的比例高于农村地区。Objectives To investigate the laboratory and epidemiological characteristics of hand-foot-mouth disease（HFMD） among repeated infection populations in Guangdong Province and to provide foundation for developing strategies for HFMD prevention and control.Method Reported HFMD cases from Jan 1,2009 to December 31,2011 were collected from the ＂China Information System for Disease Control and Prevention＂for epidemiological analysis.All of the collected records were sorted by ping-yin characters and equally divided into 10 segments.One of the ten segments was randomly selected as sample after excluding the repeated report items.Repeated infection cases within the sample segment were also determined.Descriptive analysis was employed to determine the epidemiological characteristics,while consistency coefficient was used to examine the pathogenic characteristics of repeated HFMD infection.Results 57549 record items were obtained according to sampling rules.2.09% of the reported cases experienced repeated infection within 3 years since the first onset of disease,with a median interval between two disease onsets of 9.8 months（1-34.5 months）.Children below 3-year-old accounted for 82.10% of all repeated infection cases.Mean age of first HFMD onset was 1.94 year.The proportion of repeated infection cases of the Pearl River Delta region was 2.38%,the other region was 1.45%;The proportion of repeated infection cases of urban was 2.28%,the proportion of rural was 1.86%.Conclusions Due to the diversity of pathogens causing HFMD and lack of cross immunity,approximately 2% of the infected population experienced a later repeated HFMD infection within 3 years.The proportion of repeated infection cases of Pearl River Delta region higher proportion of other regions.The proportion of repeated infection cases of Urban areas higher proportion of Rural areas.

关 键 词：手足口病 重复发病 流行特征 

分 类 号：R725[医药卫生—儿科]