蚕用盐酸左氧氟沙星溶液的临床药效和安全性试验  

Clinic Pharmacodynamic and Safety Test of Levofloxacin Hydrochloride Solution of Antibacterial Drug for Silkworm Rearing

作　　者：康国平[1,2] 王玉华[1,2] 赫荣帆[2] 王娟[2] 

机构地区：[1]江苏科技大学,江苏镇江212003 [2]中国农业科学院蚕业研究所,江苏镇江212018

出　　处：《中国兽药杂志》2013年第6期39-43,共5页Chinese Journal of Veterinary Drug

摘　　要：对研制的一种新型蚕用抗菌药物———盐酸左氧氟沙星溶液进行了临床药效和安全性试验。盐酸左氧氟沙星溶液主要用于防治家蚕细菌性败血病。临床药效试验结果表明,用100 mg/L盐酸左氧氟沙星药液给感染黑胸败血病菌或卒倒芽孢杆菌的4龄起蚕连续添食3 d,防治效果与500 mg/L盐酸诺氟沙星药液比较无明显差异(x2检验,P>0.05);200 mg/L盐酸左氧氟沙星药液给感染沙雷铁氏菌的4龄起蚕连续添食3 d,防治效果明显优于500 mg/L盐酸诺氟沙星药液(P<0.05)。安全性试验结果表明,分别用200、600、1000 mg/L盐酸左氧氟沙星药液给4龄、5龄起蚕添食3 d,对家蚕的生长发育、茧质、丝质和卵质均未见明显不良影响(t检验,P>0.05),且不存在明显的剂量-反应关系。盐酸左氧氟沙星溶液对三种病原菌感染引起的家蚕细菌性败血病均有显著的防治效果。Levofloxacin hydrochloride solution was an antibacterial agent for silkworm rearing, mainly used for controlling silkworm bacterial septicemia. Clinic pharmacodynamic experimental results indicated that the control effect on silkworm septicaemia caused by Bacillus sp. or Bacillus thuringiensis Var. sotto Ishiwata with continuous administration of 100 mg/L levofloxacin hydroehloride solution for 3 days to newly exuviated silkworm larvae of the 4th instar had no significant difference compared with 500 mg/L sarafloxacin hydrochloride capsules （x2 test, P 〉 0.05 ）. The control effect on silkworm septicaemia caused by Serratia marcescens Bizio with 200 mg/L levofloxacin hydrochloride solution for 3 days was obviously better than that with 500 mg/L sarafloxaein hydrochloride （P 〈 0.05）. Safety test results indicated that administration of 200, 600, and 1000 mg/L levofloxacin hydrochloride solution respectively to the newly exuviated larvae of the 4th and 5th instars for 3 days had no significant effect on silkworm growth and development, and cocoon, silk and egg quality （ t - test, P 〉 0.05 ）, and no significant dose -response relationship was observed. These results showed that levofloxacin hydrochloride solution had better control effect on silkworm bacterial septicemia of infected by above mentioned three silkworm pathogenetic bacteria in comparison with the commonly used silkworm drug for bacterial septicemia.

关 键 词：蚕用抗菌药物 盐酸左氧氟沙星溶液 临床药效 安全性 

分 类 号：S859.796[农业科学—临床兽医学]