从受体角度研究睡眠-觉醒调控机制  

Regulatory mechanism in sleep-wake cycle:from a receptor view

作　　者：张照环[1] 刘振宇[1] 张瀚文[1] 赵忠新[1] 

机构地区：[1]第二军医大学附属长征医院神经内科,上海200003

出　　处：《中国现代神经疾病杂志》2013年第5期368-371,共4页Chinese Journal of Contemporary Neurology and Neurosurgery

基　　金：国家自然科学基金资助项目(项目编号:81070070);国家自然科学基金资助项目(项目编号:81171252);国家科技部"十二五"重大专项课题(项目编号:2011ZXJ09202-015);上海市科委科研计划重点项目(项目编号:11411950203)~~

摘　　要：生物日节律是地球生物受昼夜更替影响的普遍现象,是生命活动的基本组成,几乎涉及机体所有组织与器官的生理活动。这种全身协调的动态变化是多种机制的共同参与和信息整合。在所有参与睡眠觉醒动态循环调控的环节中,受体至关重要,为细胞内信号效应的启动点,同时亦是重要的干预靶点。对目前已知参与睡眠-觉醒循环调节受体的种类进行归纳,并对其功能研究进展进行阐述,有助于进一步了解睡眠-觉醒的生理过程,亦为干预其病理生理变化的研究提供有效信息。Circadian rhythm is a universal phenomenon driven by the day-night cycle among the living beings on the earth. It is considered a basic element of life, which involves oscillations of most physiological activity through the body. The coordination of the different physiologic activities should be attributed to the convergence of a diversity of regulatory mechanisms. Among the multiple links in sleep- wake cycle, the receptors are of primary importance. Since they initiate the downstream signaling leading to cell responses, the receptors are considered a commonly intervention target. Here we summarize the major receptors in sleep-wake regulation, along with a brief introduction of their functional findings, aiming to provide clues to further function understanding and intervention developing.

关 键 词：睡眠 觉醒 昼夜节律 受体 褪黑激素 受体 神经肽 激素类 受体 神经递质 综述 

分 类 号：R338[医药卫生—人体生理学]