The structure of prion： is it enough for interpreting the diverse phenotypes of prion diseases？  

作　　者：Chan Tian Xiaoping Dong 

机构地区：[1]State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China [2]Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China

出　　处：《Acta Biochimica et Biophysica Sinica》2013年第6期429-434,共6页生物化学与生物物理学报（英文版）

基　　金：Funding This work was supported by the grants from the National Natural Science Foundation of China （81101302, 31270185）, China Mega-Project for Infectious Disease （2011ZX10004-101, 2012ZX10004215）, and SKLID Development Grant （2012SKLID102）.

摘　　要：Prion diseases, or transmissible spongiform encephalop- athies, are neurodegenerative diseases, which affect human and many species of animals with 100% fatality rate. The most accepted etiology for prion disease is ＇prion＇, which arises from the conversion from cellular PrPC to the pathological PrPSc. This review discussed the characteristic structure of PrP, including PRNP gene, PrPc, PrPSc, PrP amyloid, and prion strains.Prion diseases, or transmissible spongiform encephalop- athies, are neurodegenerative diseases, which affect human and many species of animals with 100% fatality rate. The most accepted etiology for prion disease is ＇prion＇, which arises from the conversion from cellular PrPC to the pathological PrPSc. This review discussed the characteristic structure of PrP, including PRNP gene, PrPc, PrPSc, PrP amyloid, and prion strains.

关 键 词：PRP PRPC prion disease PrP structure 

分 类 号：S852.659.7[农业科学—基础兽医学] Q255[农业科学—兽医学]