PAI-1基因4G/5G多态性与中国地区原因不明习惯性流产的Meta分析(英文)  

Plasminogen Activator Inhibitor-1 4G/5G Gene Polymorphism and Recurrent Spontaneous Abortion in China:A Meta-analysis

作　　者：王晓慧[1] 姜文洁[1] 张东峰[1] 谢竹田[1] 赵新新[1] 

机构地区：[1]青岛大学医学院公共卫生学院,山东青岛266021

出　　处：《现代生物医学进展》2013年第16期3029-3031,共3页Progress in Modern Biomedicine

摘　　要：目的:探讨PAI-A基因4G/5G多态性跟中国地区原因不明习惯性流产的关系。方法:采用Stata10.0对所有纳入结果进行异质性检验,敏感分析,影响分析和发表偏移检验。结果:6篇文章共540名病例和672名对照纳入研究。敏感性分析之后,4G/5G多态性跟习惯性流产明显相关(显性模型OR=1.934,95%CI=1.355-2.760,隐性模型OR=1.657,95%CI=1.142-2.405),共显性模型OR=1.604,95%CI=1.309-1.965)。结论:PAI-1基因4G/5G可能与中国地区原因不明习惯性流产有关。但仍然需要更多的实验证实。Objective：To investigate the association of the plasminogen activator inhibitor-1（PAI-1） 4G/5G polymorphism with the risk of recurrent spontaneous abortions（RSA） in China.Methods： Heterogeneity testing,Sensitivity analysis,Influence analysis and Publication bias were performed by using STATA 10.0.Results： 6 articles with 540 cases and 672 controls were chosen.After sensitivity analysis,this meta-analysis showed a significant association of 4G with increased risk of RSA in dominant（FEM OR=1.934,95%CI=1.355-2.760）,recessive（FEM OR=1.657,95%CI=1.142-2.405）,codominant（FEM OR=1.604,95%CI=1.309-1.965） model.Conclusion： 4G/5G of PAI-1 gene is associated with increased risk of RSA.However,more convincing evidence is required to draw a solid conclusion.

关 键 词：PAI-1 基因多态性 习惯性流产 

分 类 号：R714.21[医药卫生—妇产科学]