随机尿、晨尿视黄醇结合蛋白对早期肾功能损伤的诊断价值  

Random Urine, Urinary Retinol-binding Protein in Early Diagnosis of Renal Injury

作　　者：袁育林[1] 覃桂芳[1] 农生洲[1] 杜武杰[1] 阳文辉[1] 赵红英[1] 

机构地区：[1]广西壮族自治区人民医院检验科,广西南宁530021

出　　处：《现代生物医学进展》2013年第16期3135-3138,共4页Progress in Modern Biomedicine

基　　金：广西壮族自治区卫生厅科研课题(Z2012548)

摘　　要：目的:探究随机尿、晨尿视黄醇结合蛋白对早期肾功能损伤的诊断价值。方法:选取我院2011年8月-2012年9月收治的48例II型糖尿病患者,按照随机数字表进行平均分组,随机尿组24例,选取任意时段尿液标本,晨尿组24例,选取清晨时段尿液标本。对两组患者尿液标本进行尿视黄醇结合蛋白(Urinary Retinol-binding Protein,U-RBP)、尿微量白蛋白(Urinary Microalbum,U-mAlb)及尿N-乙酰-β-D氨基葡萄糖苷酶(Urinary N-acetyl beta-D-Glucosaminidase,NAG)水平测定,进行相关性分析并观察两组诊断阳性率。结果:随机尿组U-RBP、U-mAlb及NAG分别为(1.7±0.9)mg/L、(76.2±41.5)mg/L及(41.2±30.0)U/L;晨尿组U-RBP、U-mAlb及NAG分别为(3.6±1.2)mg/L、(118.5±71.)mg/L及(116.5±71.9)U/L。两组患者尿液检测指标均高于正常值,且晨尿组指标较随机尿组更高,两组数据对比存在统计学差异;随机尿组U-RBP、U-mAlb及NAG阳性例数分别为12例、6例及4例,晨尿组U-RBP、U-mAlb及NAG阳性例数分别为17例、13例及11例,晨尿组U-RBP、U-mAlb及NAG阳性率均高于随机尿组,两组数据对比存在统计学差异;随机尿组U-RBP与肾损伤相关性r=0.532,P>0.05,无明显相关性;晨尿组U-RBP与肾损伤相关性r=0.867,P<0.01,呈高度正相关。结论:随机尿及晨尿均可指示患者肾损伤出现,但随机尿蛋白指标无法有效指示肾损伤程度,对早期肾功能损害确诊准确率有限,而晨尿尿蛋白正常排泄率更高,且能够有效指示肾损伤程度,适用于糖尿病早期肾功能损伤的诊断及监测。Objective： To explore the random urine,urinary retinol binding protein for early diagnosis of renal injury.Methods： 48 patients with type II diabetes patients in our hospital from August 2011 to August 2012 were selected and divided into two groups on the basis of random table.Random urine group ： 24 cases,selected urine of any time;Urinary group： 24 cases,selected urine in the morning.Urine specimens of two groups of patients urinary retinol-binding protein,microalbuminuria and urinary N-acetyl beta-D Glucosaminidase levels were measured,the correlation analysis and positive rate in observation group two diagnosis.Results： The random urine group： U-RBP,U-mAlb and NAG were respectively（1.7 ±0.9） mg/L,（76.2 ±41.5） mg/L and（41.2 ±30） U/L;urinary group： U-RBP,U-mAlb and NAG were（3.6 ±1.2） mg/L,（118.5 ±71） mg/L and（116.5 ±71.9） U/L.Normal values were higher in two groups of patients urine testing index,and morning urine group index than random urine were higher,and there are significant differences between two groups of data comparison;random urine U-RBP,U-mAlb and NAG positive cases were 12 cases,6 cases and 4 cases,urinary U-RBP,U-mAlb and NAG positive cases in 17 cases,difference in 13 cases and 11 cases,urinary U-RBP,U-mAlb and NAG positive rate was higher than the random urinary group,there was significant difference in two groups of data comparison;random urine group U-RBP renal injury and the correlation between r=0.532,P0.05,no significant correlation;urinary U-RBP and renal injury associated with r=0.867,P0.01,showed a highly positive correlation.Conclusion： It is suggested that the random urine and urinary can indicate renal injury patients,but the random urinary protein indicators can not be effective indicator of renal injury severity,early renal damage of diagnosed accuracy is limited,and the morning pee normal protein excretion rate higher,and can effectively indicate the degree of renal injury,suitable for diagnosis and monitoring of early renal function in

关 键 词：随机尿 晨尿 视黄醇结合蛋白 肾功能损伤 诊断 

分 类 号：R544.1[医药卫生—心血管疾病]