含凝血酶敏感素1型基序的解聚素样金属蛋白酶在冠心病中作用的研究进展  

Research Progress on the Effect of a Disintegrin and Metalloproteinase with Thrombospondin Motifs 1 on Coronary Heart Disease

作　　者：李军[1] 文红艳[2] 

机构地区：[1]南华大学附属第一医院,湖南衡阳421001 [2]湖南中医药大学,湖南长沙410208

出　　处：《现代生物医学进展》2013年第16期3193-3196,共4页Progress in Modern Biomedicine

基　　金：湖南省科学技术厅科技计划重点项目(2009SK2010)

摘　　要：含凝血酶敏感素1型基序的解聚素样金属蛋白酶(a disintegrin and metalloproteinase with thrombospondin motifs 1,ADAMTS-1)可降解细胞外基质中的多能蛋白聚糖,促进平滑肌细胞的迁移,参与动脉粥样硬化的发生,并能进一步活化粥样斑块,促进斑块破裂;还可抑制血管的新生、参与胶原代谢加速心室重构、心肌纤维化等病理过程的进展,与各种类型的冠心病如稳定型心绞痛(stable angina,SA)、急性冠脉综合征(acute coronary syndrome,ACS)、缺血性心肌病(ischemic cardiomyopathy,ICM)均密切相关。研究表明,ADAMTS-1有助于冠脉狭窄程度评估、斑块稳定性判断、ACS的辅助诊断及治疗策略的选择,有望用于冠心病的危险分层和预后评估,并可能成为动脉粥样硬化和各种类型冠心病预防和治疗的新靶点。本文将就ADAMTS-1在冠心病中作用的研究进展进行综述。A disintegrin and metalloproteinase with thrombospondin motifs 1（ADAMTS-1） played a role in the development of atherosclerosis by cleaving extracellular matrix proteins such as versican,promoting vascular smooth muscle cells（VSMCs） migration and further activated atheromatous plaque to make it easy to burst.It was also involved in various pathological processes such as inhibiting the angiogenesis,participating in myocardial fibrosis and ventricular remodeling and closely related to different types of coronary heart diseases,such as stable angina（SA）,acute coronary syndrome（ACS）,ischemic cardiomyopathy（ICM）.It was showed that ADAMTS-1 could be used in the evaluation of the severity of coronary stenosis and plaque instability,auxiliary diagnosis of ACS,as well as the choose of therapeutic options,which may become a new target for the prevention and treatment of different types of coronary heart diseases.This article was aimed to review the research progress on the effect of ADAMTS-1 on coronary heart disease.

关 键 词：含凝血酶敏感素1型基序的解聚素样金属蛋白酶 动脉粥样硬化 冠心病 研究进展 

分 类 号：R541[医药卫生—心血管疾病]