不同亚型自身免疫性肝病患者隐匿性乙型肝炎病毒感染调查  

Investigation of occult hepatitis B virus infections in patients with different subtypes of autoimmune liver diseases

作　　者：钱金花[1] 徐庆武[2] 马丽苹[3] 

机构地区：[1]河北省中医院脾胃病二科,河北石家庄050017 [2]河北医科大学研究生学院,河北石家庄050011 [3]白求恩国际和平医院老年病科,河北石家庄050000

出　　处：《中华医院感染学杂志》2013年第12期2932-2934,共3页Chinese Journal of Nosocomiology

基　　金：河北省科技厅指导性项目(11276170)

摘　　要：目的观察2011年1月-2013年3月收治的自身免疫性肝病患者的临床特点、隐匿性乙型肝炎病毒(HBV)感染以及相关影响因素,为探索更有效的早期发现自身免疫性肝病提供依据。方法选取2011年1月-2013年3月门诊及住院诊断为自身免疫性肝病的81例患者为观察对象,根据患者不同亚型分为自身免疫性肝炎组(AIH组)23例、原发性胆汁性肝硬化组(PBC组)9例及原发性硬化胆管炎组(PSC组)49例,并选取门诊健康体检者87例作为对照组,比较4组人群不同亚型的自身免疫性肝病患者隐匿性HBV感染情况。结果 AIH组男女比例为1∶22,PSC组为1∶3.5,PBC组为1∶23.5,女性多于男性;≥50岁的老年患者较多;AIH组、PSC组、PBC组3组患者隐匿性HBV感染率分别是13.04%、11.11%、16.33%,高于健康对照组(P<0.05);HBV检测阳性与患者的性别、年龄以及血清IGG、血清IGM等指标之间,差异无统计学意义。结论自身免疫性肝病的临床表现特点与国内报道研究结果相近,老年女性好发,抗体阳性表达率为75.51%;且ALD患者隐匿性HBV感染率较高。OBJECTIVE To observe the clinical characteristics of the patients with autoimmune liver disease who were enrolled the hospital from Jan 2011 to Mar 2013 and the analyze the related risk factors of the occult hepatitis B virus （HBV） infections so as to explore a more effective way to find the autoimmune liver disease in the early stage. METHODS A total of 81 cases of patients, who were diagnosed as the autoimmune liver disease in the hospital from Jan 2011 to Mar 2013, were enrolled in the study and were divided into the autoimmune hepatitis group （AIH group） with 23 cases, the primary biliary cirrhosis group （PBC group） with 9 cases, and the primary sclerosing cholangitis （PSC group） with 49 cases, while 87 cases of healthy individuals who took physical exami- nation in the outpatients department were chosen as the control group, then the incidence of occult HBV infections was compared between the four groups of patients with difference subtypes of autoimmune liver diseases. RESULTS The male to female ratio was 1 ： 22 in the AIH group, the PSC group 1 ： 3.5, the PBC group 1 ： 23.5, the female patients were more than the male patients; the senile patients aged more than 50 years old were the main population. The incidence rate of the occult HBV infections was 13.04% in the AIH group, 11.11% in the PSC group, and 16.33% in the PBC group, which were higher than that of the control group （P〈0.05）. The difference in such indicators as the gender, age, serum IGG, or serum IGM between the HBV-positive patients was not statistically significant. CONCLUSION The clinical characteristics of the autoimmune liver diseases are similar to the domestic reported findings, with the predilection in the senile female. The positive antibody expres- sion rate was 75.51%. The incidence rate of HBV infections is relatively high in the ALD patients.

关 键 词：自身免疫性肝病 临床特点 肝炎病毒 分析 

分 类 号：R512.62[医药卫生—内科学]