骨愈方中羟基红花黄色素A的体外透皮性能考察  

Investigation of in vitro Transdermal Property of Hydroxysafflor Yellow A in Guyu Prescription

作　　者：温然[1] 郝博[2] 高瑛 陆洋[1] 李慧云[1] 赵雪姣[1] 

机构地区：[1]北京中医药大学中药学院,北京100102 [2]国家药典委员会,北京100061 [3]北京市顺义区中医医院,北京101300

出　　处：《中国实验方剂学杂志》2013年第12期40-42,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：北京市中医药科技项目(JJ2011-36)

摘　　要：目的:研究骨愈方中羟基红花黄色素A的体外透皮释药情况。方法:采用垂直式Franz扩散池进行小鼠离体皮肤透皮吸收试验,以羟基红花黄色素A(HSYA)含量为指标,考察乙醇体积分数和药物浓度对HSYA透皮性能的影响。结果:药液质量浓度和乙醇体积分数的增加均有利于HSYA透过皮肤;选择生药质量浓度1 g.mL-1,乙醇体积分数70%。结论:70%乙醇可显著促进HSYA的皮肤透过作用,为骨愈搽剂的制备提供参考。Objective： To investigate in vitro transdermal behavior of hydroxysafflor yellow A（HSYA） in Guyu prescription.Method： Percutaneous absorption test was performed on excised mice skin in Franz diffusion cell,with the content of HSYA as index,effect of the concentration of ethanol and drug on transdermal property of HSYA was investigated.Result： The accumulation skin permeation ratio of HSYA with 20% ethanol,50% ethanol and 70% ethanol were 1.26%,1.69%,5.28%,respectively;And results of 0.5,1,2 g.mL-1 of drug solution were 1.06%,1.26%,1.50%,respectively.Increasing of the concentration of ethanol and drug solution were conducive HSYA through skin;the concentration of 1 g.mL-1and 70% were selected.Conclusion： 70% ethanol could significantly promote transdermal property of HSYA,it could provide a reference for preparing Guyu liniments.

关 键 词：骨愈方 羟基红花黄色素A 透皮吸收 

分 类 号：R283.6[医药卫生—中药学]