白花蛇舌草中熊果酸的透皮吸收试验  

Transdermal Absorption Test of Ursolic Acid in Hedyotis diffusa

作　　者：努尔拉江.帕合尔丁 吐鲁洪.卡地尔 沈腾[3] 西尔艾力.吐尔逊 

机构地区：[1]新疆维吾尔自治区维吾尔医医院,乌鲁木齐830049 [2]新疆维吾尔自治区维吾尔医药研究所,乌鲁木齐830049 [3]复旦大学药学院,上海200032

出　　处：《中国实验方剂学杂志》2013年第12期49-52,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：上海市科学技术委员会中药现代化专项(07DZ19713);国家重大科技专项(2009ZX09310-006)

摘　　要：目的:考察白花蛇舌草中熊果酸的透皮吸收特性。方法:采用HPLC测定熊果酸含量。选择SD大鼠背部皮肤,通过Franz垂直扩散池考察熊果酸的透皮性能,并考察氮酮(azone)、桉叶油、冰片、白花蛇舌草水提取物和醇提取物对熊果酸透皮吸收的影响。结果:熊果酸很难透过皮肤,需加入透皮吸收促进剂才能有效地透过皮肤。不同质量分数促进剂对熊果酸促透作用顺序为5%醇提物>5%醇提物+2%冰片>5%水提物>2%azone+10%丙二醇(PG)>2%桉叶油>4%azone>3%桉叶油>2%azone>1%azone。结论:Azone和桉叶油是白花蛇舌草中熊果酸的良好促透剂,复方水提取物和醇提物具有协同促透的作用。Objective： To investigate transdermal absorption characteristics of ursolic acid in Hedyotis diffusa.Method： The content of ursolic acid was determined by HPLC.Utilized skin on the back of SD rats,Franz vertical diffusion cell was adopted to investigate transdermal performance of ursolic acid,and effect of azone,eucalyptus oil,synthetic borneol,water extract and alcohol extract of H.diffusa on transdermal performance of ursolic acid was investigated.Result： Ursolic acid was difficult to penetrate the skin,it must be added to certain transdermal absorption enhancer.Effect of enhancers on ursolic acid was in order of 5% ethanol extract ＆gt; 5% ethanol extract ＋ 2% borneol ＆gt; 5% water extract ＆gt; 2% azone ＋ 10% PG ＆gt; 2% eucalyptus oil ＆gt; 4% azone ＆gt; 3% eucalyptus oil ＆gt; 2% azone ＆gt; 1% azone.Conclusion： Azone and eucalyptus oil was good penetration enhancers for ursolic acid in H.diffusa,compound water extract and ethanol extract had a collaborative effect in promoting penetration.

关 键 词：白花蛇舌草 熊果酸 透皮吸收 促进剂 

分 类 号：R283.6[医药卫生—中药学]