乳癖消减方抗实验性大鼠乳腺增生作用  

Experimental Study on Effect of Modified Formula Rupixiao on Mammary Hyperplasia Rats

作　　者：姜云云[1] 叶光明[1] 沐韦[1] 刘海[1] 陈云红[1] 

机构地区：[1]解放军第101医院,江苏无锡214044

出　　处：《中国实验方剂学杂志》2013年第12期269-272,共4页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:观察乳癖消减方对实验性大鼠乳腺增生的治疗作用。方法:用苯甲酸雌二醇和黄体酮致大鼠乳腺增生模型,将大鼠随机分为空白对照组、模型对照组、乳癖消片组(生药4 g.kg-1)、乳癖消减方高、中、低剂量组(生药8,4,2 g.kg-1),模型对照组15只,其余每组各10只。大鼠连续ig给药9周,用放射免疫法测定大鼠血清雌二醇、孕酮水平,并对第二、三对乳房常规固定染色后进行病理学检查。结果:乳癖消减方低剂量组治疗效果不明显,乳癖消减方中、高剂量组不仅可以使乳腺增生大鼠雌二醇与孕酮的比值恢复正常(P<0.01),且能显著改善模型大鼠乳腺增生引起的病理改变。结论:乳癖消减方对大鼠乳腺增生具有显著的治疗作用。Objective： To observe the therapeutic effect of modified formula Rupixiao on mammary hyperplasia rats.Method： Rat models with hyperplasia of mammary glands were established by injection of estradiol benzoate and progesterone.The rats were randomly divided into control group,vehicle group,Rupixiao tablet group（4 g.kg-1） and modified formula Rupixiao groups（8,4,2 g.kg-1）.There were 15 rats in vehicle group,and 10 rats in each of other group.The rats were orally administrated with drugs for 9 weeks.The contents of estradiol and progesterone in rat plasma were measured by radioimmunity,and the pathologic examination was carried out on the second and third pairs of breasts after usual fixation and staining.Result： Modified formula Rupixiao 2 g.kg-1 of did not have obvious therapeutic effect on mammary hyperplasia rats.Modified formula Rupixiao 4,8 g.kg-1could not only make the ratio of estradiol to progesterone back to normal（P ＆lt; 0.01） but also improved their pathologic status.Conclusion： Modified formula Rupixiao has conspicuous therapeutic effect on mammary hyperplasia rats.

关 键 词：乳癖消 乳癖消减方 乳腺增生 性激素 

分 类 号：R285.5[医药卫生—中药学]