清肝化痰活血方治疗非酒精性脂肪肝炎78例  

Therapeutic Efficacy of Qinggan Huatan Huoxue Recipe in Treatment of 78 Cases with NASH

作　　者：裴强[1] 王晓素[2] 王宪波[3] 李英[2] 刘晓楠[2] 

机构地区：[1]新乡医学院第一附属医院,河南卫辉453100 [2]上海中医药大学附属岳阳中西医结合医院,上海200437 [3]首都医科大学附属北京地坛医院,北京100015

出　　处：《中国实验方剂学杂志》2013年第12期303-306,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：上海市卫生局课题(2004L003A)

摘　　要：目的:探讨清肝化痰活血方对非酒精性脂肪性肝炎(NASH)患者临床症状及肝脏影像学的影响。方法:150例NASH患者随机分为治疗组(78例)和对照组(72例)。治疗组口服清肝化痰活血方(100 mL,2次/d,口服),对照组口服胆宁片(5片/次,3次/d,口服),疗程均为3个月。观察两组治疗前后临床症状、肝脏B超积分和肝脾CT比值。结果:治疗组临床总有效率明显高于对照组(87.2%vs 73.6%),且治疗组在改善胁肋胀痛、烦躁易怒、恶心呕吐和口干口苦症状方面明显优于对照组,差异均有统计学意义(P<0.05)。治疗前两组肝脏B超积分和肝脾CT比值比较,差异均无统计学意义;与该组治疗前比较,治疗后两组肝脏B超积分下降,肝脾CT比值升高,差异均有统计学意义(P<0.05),且治疗组作用明显优于对照组(P<0.05)。两组均无明显不良反应发生。结论:清肝化痰活血方对NASH患者临床症状及肝脏影像学的改善具有确切治疗作用,且疗效优于胆宁片。Objective： To study the therapeutic effects of Qinggan Huatan Huoxue recipe（QHHR） on clinical symptoms and liver imageology of patients with non-alcoholic steatohepatitis（NASH）.Method： One hundred and fifty NASH patients were randomly assigned to the treatment group（78 cases） and the control group（72 cases）.QHHR was given to patients in the treatment group while Danning tablet was given to patients in the control group.The course of treatment was three months.Before and after the treatment changes of clinical symptoms,integral of liver ultrasound B and CT ratio of liver-spleen were observed.Result： The total effective rate of the treated group was higher than that of the control group and better effects were obtained in the amendment of the clinical symptom of thypochondrium distending pain,restlessness or tantrum,nausea or emesis and dry mouth or bitter taste of mouth（P ＆lt; 0.05）.Compared with before treatment.The integral of liver ultrasound B were significantly reduced and the CT ratio of liver-spleen was significantly increased in two groups（P ＆lt; 0.05）.After treatment,the treated group was superior to the control group in the descended integral of liver ultrasound B and increased extent of the CT ratio of liver-spleen（P ＆lt; 0.05）.Conclusion： QHHR had definite effects on the improvement of clinical symptom and liver imageology of patients with NASH.Its therapeutic effects were better than Danning tablet.

关 键 词：清肝化痰活血方 非酒精性脂肪性肝炎 肝脾CT比值 

分 类 号：R287[医药卫生—中药学]