丹七散瘀搽剂的皮肤用药安全性评价  

Safety Evaluation of Danqi Sanyu Linim for Skin Administration

作　　者：杨芳[1] 杨喜花[2] 张蕻 阎磊[2] 白喜花[2] 任连生[2] 

机构地区：[1]山西省肿瘤医院药学部,太原030013 [2]山西省肿瘤研究所比较医学部,太原030013 [3]山西省食品与药品检验所药理室,太原030001

出　　处：《光明中医》2013年第6期1112-1114,共3页GUANGMING JOURNAL OF CHINESE MEDICINE

摘　　要：目的观察丹七散瘀搽剂对豚鼠皮肤的过敏性和大鼠皮肤的刺激性实验,评价其对皮肤用药的安全性。方法皮肤过敏性实验选用豚鼠作为实验动物,采用外敷给药,阳性对照药选用2,4-二硝基氯代苯,观察比较给药后不同时间两组动物给药局部皮肤的反应;皮肤刺激性实验选用大鼠为实验动物,分为皮肤破损组和正常皮肤组,采用涂抹给药,观察比较给药后两组动物的皮肤反应,分别按照评分标准评分后进行比较。结果丹七散瘀搽剂对豚鼠皮肤无红斑及水肿等过敏性反应,反应级数为零,致敏率为零;对大鼠皮肤亦无明显刺激性反应,反应级数均为零。结论丹七散瘀搽剂在动物皮肤实验中无过敏及刺激现象产生,其皮肤用药安全性良好。Abstract：Objective To observe the safety of Danqi Sanyu linim for skin administration. Methods Guineas were used for skin allergy test and the reflection after Danqi Sanyu linim was applied externally for observation. Rats were chose to study the skin irritancy and were both applied with Danqi Sanyu linim in the normal skin group and injured skin group. The reflection after the drug administration was observed. Results All guineas and rats didn＇t appear erythema and edema. The reaction orders and the sensitization rates were all zero. Conclusion There was no skin irritancy and allergy occurred when applied with Danqi Sanyn iinim which showed good skin safety.

关 键 词：丹七散瘀搽剂 安全性评价 皮肤过敏实验 皮肤刺激实验 

分 类 号：R285[医药卫生—中药学]