地塞米松联合异烟肼鞘内注药治疗结核性脑膜炎疗效分析  

Analysis of the Efficacy of Intrathecal Injection of Dexamethasone Combined with Isoniazid for Tuberculous Meningitis

作　　者：谢靖婧[1] 周安民[1] 彭丽红[1] 钟哲峰[1] 何剑[1] 

机构地区：[1]南华大学附属南华医院感染科,湖南衡阳421002

出　　处：《中南医学科学杂志》2013年第3期304-306,共3页Medical Science Journal of Central South China

摘　　要：目的观察地塞米松联合异烟肼鞘内给药治疗结核性脑膜炎的临床疗效。方法将临床确诊的60例结核性脑膜炎患者回顾性均分两组,两组均采用常规抗结核治疗联合使用脑脊液置换加鞘内给药治疗方案,对照组单用异烟肼鞘内注药,治疗组采用地塞米松联合异烟肼鞘内注药。观察两组患者临床症状与体征变化,颅内病灶吸收情况和脑脊液的变化。结果地塞米松联合异烟肼给药4周后脑脊液检测基本恢复正常,患者症状与体征均显著改善,颅内压力降至正常,脑脊液的白细胞数、蛋白、糖、氯化物的恢复时间均短于对照组。结论地塞米松联合异烟肼鞘内给药是治疗结核性脑膜炎更为有效的方法。Objective To investigate the clinical efficacy of intrathecal injection of dexamethasone combined with isoniazid for tuberculous meningitis.Methods The 60 cases of clinically confirmed tuberculous meningitis patients were randomly divided into two groups,both of which were given conventional anti-tuberculous treatment combined with cerebrospinal fluid（CSF） replacement and intrathecal drug treatment.The control group was treated by isoniazid intrathecal injection,and the treatment group was given dexamethasone combined with isoniazid intrathecal injection.Then observe the change of the clinical symptoms and physical signs,the absorption of the intracranial lesions and the cerebrospinal fluid of both groups.Results After four weeks,for the group given dexamethasone combined with isoniazid,the results of cerebrospinal fluid detection basically returned to normal,and the clinical symptoms and physical signs improved significantly and the intracranial pressure dropped to normal;the period during which their White blood cell count,protein,glucose,chlorides in CSF returned to normal was shorter than that of the control group.Conclusion The intrathecal injection of dexamethasone combined with isoniazid is a more effective therapeutic method for tuberculous meningitis.

关 键 词：联合治疗 鞘内注药 结核性脑膜炎 

分 类 号：R51[医药卫生—内科学]