前列地尔脂微球载体制剂治疗老年周围动脉硬化闭塞性疾病的临床分析  

Clinical analysis of alprostadil lipid microsphere carrier preparation treatment for senile surrounding arteriosclerosis occlusive disease

作　　者：孔海英[1] 徐澜 

机构地区：[1]杭州钢铁集团公司职工医院药剂科,杭州310022 [2]浙江老年关怀医院,杭州310015

出　　处：《实用药物与临床》2013年第5期412-414,共3页Practical Pharmacy and Clinical Remedies

摘　　要：目的探讨前列地尔脂微球载体制剂治疗老年周围动脉硬化闭塞性疾病的临床疗效。方法我院收治的老年周围动脉硬化闭塞性疾病患者65例,所有患者均在原有的常规治疗基础上加用前列地尔脂微球载体制剂。观察治疗前后患者的症状、体征、实验室检查、动脉狭窄情况以及血流峰速的改变情况。结果患者的临床症状得到不同程度的改善,13例完全消失,31例明显好转,21例无变化;患者的无症状行走距离较治疗前平均增加(151.75±12.43)m,P<0.05;未发生严重的不良反应。结论前列地尔脂微球载体制剂治疗老年周围动脉硬化闭塞性疾病疗效确切,不良反应少。Objective To investigate the curative effect of alprostadil lipid microsphere carrier preparation on senile surrounding arteriosclerosis occlusive disease. Methods 65 elderly patients with senile surrounding arteriosclero- sis occlusive disease admitted to our hospital were given alprostadil lipid microsphere carrier preparation treatment on the basis of conventional treatment. The patient＇ s symptoms, signs and laboratory tests, artery stenosis and the blood flow peak speed changes were observed before and after treatment. Results The patients＇ clinical symptoms got differ- ent degree of improvement, 13 cases completely disappeared, 31 cases improved obviously,21 cases had no change;Pa- tients＇ asymptomatic walking distance increased on an average of（ 151.75 ± 12.43 ）m after treatment（ P 〈 0.05 ） ;No serious adverse event occured. Conclusion Alprostadil lipid microsphere carrier preparation treatment for senile sur- rounding arteriosclerosis occlusive disease has definite effect with less adverse reactions.

关 键 词：前列地尔脂微球载体制剂 周围动脉硬化闭塞性疾病 老年患者 

分 类 号：R543[医药卫生—心血管疾病]