静电纺丝技术制备载药聚乙烯醇-海藻酸钠纳米纤维  

Preparation of Drug-Loaded Polyvinyl Alcohol-Sodium Alginate Nanofiber by Electrospinning

作　　者：李沉纹[1] 管海燕[1] 李卓恒[1] 于彩平[1] 罗明和[1] 卢来春[1] 

机构地区：[1]第三军医大学大坪医院野战外科研究所药剂科,重庆400042

出　　处：《中国药学杂志》2013年第12期980-985,共6页Chinese Pharmaceutical Journal

摘　　要：目的以盐酸莫西沙星作为模型药物,采用静电纺丝技术制备载药聚乙烯醇-海藻酸钠纳米纤维,并考察其释药性能。方法 采用星点设计-效应面优化法设计纳米纤维处方,考察聚乙烯醇、海藻酸钠的浓度、聚乙烯醇与海藻酸钠的比例对药物释放率的影响。以CaCl2乙醇溶液作为交联剂增加纳米纤维的抗水性能。通过光学显微镜和扫描电镜观察纳米纤维的形貌。检测载药率,并测定药物释放,对释放曲线进行拟合。结果 纳米纤维载药率均在65%以上。药物的释放符合Fick扩散定律,聚乙烯醇和海藻酸钠的浓度、两者比例与药物释放率之间符合二项式方程。结论制得的盐酸莫西沙星-聚乙烯醇-海藻酸钠纳米纤维显示出良好的释药特性,作为载药系统具有较好的应用前景。OBJECTIVE To fabricate moxifloxacin hydrochloride-loaded polyvinyl alcohol （PVA）-sodium alginate （SA） nanofiher using the electrospinning technique and investigate the drug release in vitro. METHODS Central composite design-response surface methodology was used to investigate the influences of various factors, i. e. , PVA content, SA content, the ratio of PVA-SA, on the accumulated release rate of moxifloxacin hydrochloride from the nanofibers. The scaffolds were cross-linked by CaCl2 ethanol solution. Fiber morphology was characterized using optical microscope and scanning electron microscopy （ SEM ）. Drug entrapment efficiency was determined, and drug release profiles were tested. RESULTS Moxifloxacin hydroehloride entrapment efficiencies were well above 65%. Drug was released from the nanofibers as a linear function of the square root of time, suggesting accordance with Fickian kinetics. The relationship between the independent variables and the dependent variables was in accordance with quadralic model. CONCLUSION The PVA-SA nanofiber presents good release characteristics, and has a good prospect as drug carrier.

关 键 词：电纺纳米纤维 聚乙烯醇 海藻酸钠 释放度 

分 类 号：O636.9[理学—高分子化学] R944[理学—化学]