核因子-κB1基因启动子区多态性与广东地区鼻咽癌的关联研究  

Study on the association between the polymorphism of the promoter of factor-κB1 gene and nasopharyngeal carcinoma in Guangdong

作　　者：刘叶花[1] 杨磊[1] 丘福满[1] 吕嘉春[1] 纪卫东[1] 

机构地区：[1]广州医学院公共卫生学院,广东广州510182

出　　处：《现代预防医学》2013年第12期2185-2188,共4页Modern Preventive Medicine

基　　金：广东省高等学校高层次人才项目(30972540);国家自然科学基金项(81078366);国家自然科学基金项目(30872178)

摘　　要：目的探讨核因子-κBl(NFΚB1)基因启动子区-94ins/delATTG多态与鼻咽癌易感性的关系。方法应用病例对照研究的方法,采用TaqMan基因型检测法对300例鼻咽癌原发病例和300例健康对照进行基因型检测,运用SAS9.13软件对研究位点基因型与鼻咽癌进行关联分析。结果 NFΚB1基因-94ins/delATTG多态位点基因型分布在鼻咽癌病例和对照组中的差异有统计学意义(P=0.01),且鼻咽癌的发病风险随着-94ATTGins等位基因个数呈显著的剂量效应关系(Ptrend=0.003),以-94del/delATTG基因型为参照,-94ins/insATTG基因型携带者发生鼻咽癌的危险性增高(Adjusted OR=2.02,95%CI=1.26～3.23),-94insATTG等位基因携带者发生鼻咽癌的危险是-94del/delATTG的1.65倍(Adjusted OR=1.65,95%CI=1.09～2.49)。结论 NFΚB1基因启动子区-94ins/delATTG多态与鼻咽癌相关,该位点insATTG等位基因可能是鼻咽癌的一个遗传易感基因。OBJECTIVE To investigate the relationship between the -94ins/delATrG polymorphism of NFKB1 gene and nasopharyngeal carcinoma （NPC）. METHODS Based on a hospital ease-control study, 300 patients with NPC and 300 healthy participants were genotyped the SNP of -94ins/delATrG polymorphism by the TaqMan SNP genotyping assays. The association between the distributions of three genotypes and the risk of NPC was analyzed with SAS9.13 software. RESULTS There was an obvious difference in the frequencies of genotypes of the -94ins/delATI＇G polymorphisrn between NPC and control groups （P = 0.01）. The risk effect for NPC was dose-dependent on the number of -94insATrG allele （Ptrend = 0.003）. Compared with the -94del/delATrG genotype, the -94ins/insATI＇G genotype was associated with an increased risk for NPC （Adjusted OR = 2.02, 95%CI = 1.26-3.23） and the carriers with the -94ins/del or ins/insATTG genotype had a 1.65 times risk of NPC higher than people with the -94del/delATTG genotype （Adjusted OR = 1.65, 95%CI = 1.09-2.49）. CONCLUSION The -94ins/delATrG polymorphism in the promoter region of NFKB 1 gene might play an important role in the development of NPC and the -94insATTGallele can be used as a susceptibility biomarker of NPC.

关 键 词：核因子-κB1 鼻咽癌 基因多态性 

分 类 号：Q786[生物学—分子生物学]