患者报告结局的国内外研究进展  

Research process in patient-reported outcomes at home and abroad

作　　者：刘砚燕[1] 陈如男[1] 姚静静[1] 袁长蓉[1] 

机构地区：[1]第二军医大学护理学院,上海200433

出　　处：《现代预防医学》2013年第12期2268-2271,2279,共5页Modern Preventive Medicine

基　　金：上海市科学技术委员会资助项目(12410707900)

摘　　要：患者报告结局是指直接来自患者的有关患者健康状态的任何方面的信息,广泛应用于健康相关生活质量、临床试验、不良事件监测及批准药物等。患者自主报告比医生报告对患者自身状态改变更敏感,可在治疗早期就发现异常症状。患者自主报告主观性不良事件与整体健康状况一致性远远高于医生报告。将患者报告的不良事件及症状感受纳入到临床试验结局指标评价体系是近几年癌症研究领域的热点。本文就患者报告结局的概念、内容、测评工具及应用的研究进展进行综述,以期为未来开展相关研究提供指导。Patient-reported outcomes are defined as a measurement of any aspect of a patient＇s health status that comes di- rectly from the patient. And it has been used in the measurement of health-related quality of life, being endpoints of clinical trials, monitoring of adverse event and approval of new drugs and so on. Patient self-reporting is more sensitive to changes in their state than doctors＇ reporting, which could find abnormal symptoms in the early treatment. Subjective adverse events of patient self-reported consistent with the overall health is much higher than that in the medical report. It is a focus of cancer re- search that the patient reports symptoms of adverse events and feelings are included into evaluation system for clinical trial outcome measures in recent years. In this article, we summarized the research progress in the concept, content, instruments and application of patient-reported outcomes, to provide some reference for related research in future.

关 键 词：自我报告 结局 文献综述 

分 类 号：S854.46[农业科学—临床兽医学]