影响系统性红斑狼疮疾病预后的临床因素分析  

The analysis of clinical factors which affect the disease prognosis of systemic lupus erythematosus

作　　者：王海英[1] 李吴萍[2] 朱彩侠[1] 鱼云霞[1] 

机构地区：[1]宁夏医科大学总医院风湿免疫科,宁夏银川750004 [2]宁夏医科大学公共卫生学院

出　　处：《现代预防医学》2013年第12期2358-2361,共4页Modern Preventive Medicine

基　　金：宁夏自然科学基金(NZ0877)

摘　　要：目的探讨系统性红斑狼疮(SLE)患者的临床表现、实验室指标对疾病预后的影响,以期为临床正确判断SLE的转归提供更多的参考依据。方法用EpiData3.02软件建立数据库,分析2006年1月～2010年6月1037例宁夏医科大学附属医院SLE住院患者的病案资料。结果 5年来该院收治住院病例呈逐年上升趋势;1037例SLE患者中,其发病特点以20～40岁女性最为常见,占67.5%,男女比例为1︰8.26。关节痛是最常见的首发症状,占54.3%,其次是皮疹,占48.2%;预后情况:91.8%的住院患者好转出院,未愈或死亡者占8.2%。心、肺、消化系统和神经精神系统的损伤对预后结果有显著影响(P﹤0.05);影响预后结果的主要临床症状和体征是肺间质病变、肺栓塞、胸腔积液、心包积液、腹膜炎、肾脏损害和紫癜。实验室指标是血红蛋白、血小板、ds-DNA抗体阳性、血沉和C3、C4水平(P﹤0.05)。结论 SLE是多系统、多脏器受累的疾病,在临床症状和实验室指标上有其特征性改变,了解其临床表现、实验室指标对疾病预后的影响,对延缓SLE患者病情发展,改善预后具有重要意义。OBJECTIVE To investigate the clinical manifestations, laboratory index which affect the disease prognosis of systemic lupus erythematosus and to provide reference for the SLE diagnosis. METHODS EpiData 3.02 software was used to build up a database and 1037 cases SLE patients from Affiliated Hospital of Ningxia Medical University from January 2006 to June 2010 were analyzed. RESULTS Over the past 5 years, the inpatient had an upward trend year by year In the 1 037 cases of SLE patients, the incidence of the characteristics of 20-40-year-old woman was the most often seen, accounting for 67.5%, male to female ratio was 1 ： 8.26. Joint pain was the most common first symptom, accounting for 54.3%, followed by skin rash, accounting for 48.2%. Prognosis analysis： 91.8% of hospitalized patients＇ situations were improved when leaving hospital, not cured or dead accounted for 8.2%.The damage of the heart, lung, digestion system and nerve-mental symptom had an remarkable influence on the disease prognosis （P 〈 0.05）. The clinical symptoms which affected the prognosis included the interstitial lung disease, lung embolism, thoracic cavity liquid, pericardium liquid, peritonitis, renal damage and pur- puras. The laboratory index which affected the prognosis include the hemoglobin, platelets, positive of ds-DNA antibody, the erythrocyte sedimentation rate and the level of complement C3 and C4. CONCLUSION SLE is a multi-system disease with multiple organ involvement which has special clinical symptoms and immunological indicators changes. To investigate the effects of the clinical manifestations, laboratory index on tbe disease prognosis of SLE will delay the development of SLE pa- tients and improve the prognosis of great significance.

关 键 词：系统性红斑狼疮 疾病预后 临床因素 

分 类 号：R593.241[医药卫生—内科学]