越婢汤加减治疗类风湿关节炎寒热错杂证临床研究  

Clinical Research about Modified Yuebi Decoction to Treat Cold-heat Complicated Syndrome of RA

作　　者：李晶晶[1] 高忠恩[1] 

机构地区：[1]苏州市中医医院风湿科,江苏苏州215029

出　　处：《辽宁中医杂志》2013年第6期1143-1145,共3页Liaoning Journal of Traditional Chinese Medicine

摘　　要：目的:通过治疗组与对照组不同治疗RA方案的对比研究,评价以越婢汤加减治疗RA的疗效及其安全性。方法:40例符合寒热错杂证的类风湿关节炎病人,治疗组20例,以甲氨蝶呤片+双氯芬酸钠+越婢汤加减治疗;对照组20例,以甲氨蝶呤片+双氯芬酸钠治疗,疗程均为2个月。结果:治疗组总有效率95%,对照组总有效率75%,治疗组与对照组的临床体征以及VAS积分、主要中医证侯等均有显著改善(P<0.05),治疗组VAS积分的减少数高于对照组(P<0.05);实验室指标两组治疗前后比较,差异有统计学意义(P<0.05),两组间差异比较亦有统计学意义(P<0.05)。结论:中药越婢汤加减结合西药治疗RA寒热错杂证比单纯西药治疗在改善症状等方面疗效更显著,在控制疾病活动的炎性指标方面亦有确切疗效。没有明显毒副作用。Objective： To treat RA with the modified Yuebi Decoction. By contrasting the research of treatment group and the control group, to estimate the curative effect and safety. Methods ：40 RA patients belonged to the cold - heat complicated syndrome type were divided into two groups by random：the treatment group which contained 20 patients were treated with MTX 10 mg orally once a week and Dielofenae 75 mg orally once a day and modified Yuebi Decoction, and the control group which also contained 20 patients were treated with MTX 10 mg orally once a week and Diclofenac 75 mg once a day orally, and the period of treatment of two groups was 2 months. Results：The totally effective rate of the treatment group was 95 % while the rate of the control group was 75 %. There was a significant difference between the treatment group and the control group （P 〈 0. 05 ）. After treatment, the clinical and TCM symptoms of the two group patients were all significantly improved （ P 〈 0.05 ）, and the treatment group was better than the control group. The contrast result showed that laboratory index of both groups were changed after treatment（ P 〈 0. 05 ）, and there was also a significant difference between the treatment group and the control group （P 〈 0. 05 ）. Conclusion：To treat the cold - heat complicated syndrome of RA, the combination treatment of modified Yuebi Decoction and western medicine can improve the clinical presentations effect better and has a better security.

关 键 词：类风湿关节炎 类风湿关节炎 寒热错杂证 越婢汤 临床研究 

分 类 号：R593.22[医药卫生—内科学]