戊型肝炎疫苗研究进展  

Progress on Hepatitis E Vaccine

作　　者：李斌[1,2] 苏乾莲[1,2] 赵武[1,2] 秦毅斌[1,2] 梁家幸[1,2] 何颖[1,2] 闭炳芬[1,2] 梁保忠[1,2] 段群棚[1,2] 卢冰霞[1,2,3] 李莹莹[1,2,3] 姜佳佳[1,2,3] 

机构地区：[1]广西兽医研究所,广西南宁530001 [2]广西畜禽疫苗新技术重点实验室,广西南宁530001 [3]广西大学动物科学技术学院,广西南宁530005

出　　处：《动物医学进展》2013年第6期154-159,共6页Progress In Veterinary Medicine

基　　金：广西基本科研业务费专项(桂科专项10-1;桂科专项11-1);广西科技攻关项目(桂科攻10100014-4);广西畜禽疫苗新技术重点实验室系统性研究课题(12-071-28-A-5)

摘　　要：戊型肝炎(HE)是由戊型肝炎病毒(HEV)引起的病毒性肝炎,是一种重要的人兽共患传染病,呈全球分布,严重危害人体健康和动物养殖业健康发展。HEV有4种基因型(Ⅰ、Ⅱ、Ⅲ、Ⅳ型),但HEV只有1种血清型,因此应用HE疫苗进行免疫预防是最为经济、有效、可行的防控手段。迄今HEV尚不能在体外细胞中进行稳定的大量培养,从而阻碍了HEV灭活疫苗和弱毒疫苗的研制,目前HE疫苗研究重点方向是基因工程疫苗的研发。论文就4种HE基因工程疫苗(重组HEV样颗粒疫苗、重组蛋白疫苗、核酸疫苗和转基因植物可食疫苗)的研究进展做一综述。Hepatitis E（HE） is a viral hepatitis caused by hepatitis E virus（HEV）.It is a new important zoonotic infectious diseases which occurred in recent years,globally distributed,seriously harmed theful to health of people and the health development of animal breeding.There are four kinds of HEV genotype（Ⅰ,Ⅱ,Ⅲ,Ⅳ type）,but only one HEV serotype.So HE vaccine immunization is the most economical,effective and feasible prevention means for HE control.HEV still can not be stably cultured in vitro,thus impeding the development of HEV inactivated vaccine and attenuated vaccine.Now HE vaccine research focuses in research and development of genetic engineering vaccine.In this paper,the research progress of four kinds of HE genetic engineering vaccines（recombinant HEV-like particles vaccine,recombinant protein vaccine,DNA vaccine and transgenic plant edible vaccine） were reviewed.

关 键 词：戊型肝炎 人兽共患传染病 疫苗 

分 类 号：S852.4[农业科学—基础兽医学]