地奥心血康对血淤大鼠血液流变学及凝血系统的影响  

Effect of Di'aoxinxuekang on the hemorheology and blood system in blood stasis rats

作　　者：白仲梅[1] 张建强[2] 魏玉辉[2] 

机构地区：[1]靖远煤业集团有限责任公司总医院药剂科,甘肃白银730913 [2]兰州大学第一医院药剂科,甘肃兰州730000

出　　处：《兰州大学学报（医学版）》2013年第2期38-40,共3页Journal of Lanzhou University（Medical Sciences）

摘　　要：目的研究地奥心血康对血淤大鼠血液流变学及凝血系统的影响。方法采用注射盐酸肾上腺素结合冷水刺激的方法制备血淤大鼠模型,对模型及药物后大鼠血液黏度、凝血酶时间(TT)、凝血酶原时间(PT)、部分凝血活酶时间及纤维蛋白原(FIB)进行测定。结果与模型组相比,地奥心血康可以显著降低血淤大鼠的血液黏度(P<0.01);能显著降低血淤大鼠的FIB含量,延长PT和TT(P<0.05)。结论地奥心血康对血淤大鼠血液流变学及凝血系统有明显影响。Objective To study the effect of Di＇aoxinxueknng on the hemorheology and blood system in blood stasis rats. Methods The blood stasis rats were prepared by injecting adrenaline. The blood viscosity, thrombin time （TT）, prothrombin time （PT）, activated partial thromboplastin time and fibrinogen were determined. Results Compared with model group, whole blood viscosity and content of fibrinogen in blood stasis rats had been significantly reduced （P 〈0.01）; while the values of PT and TT had been prolonged （P 〈0.05）. Conclusion Di＇aoxinxuekang had a significant effect on the hemorheology and blood system in blood stasis rats.

关 键 词：地奥心血康 血淤大鼠 血液流变学 凝血系统 

分 类 号：R969.1[医药卫生—药理学]