中药联合化疗治疗初治继发性肺结核701例临床观察  

Initial Combo Therapy of Chinese Medicine and Chemotherapy for 701 Cases of Secondary Pulmonary Tuberculosis

作　　者：周建民[1] 王胜圣[1] 田洋[1] 周杰[1] 王晓岩[1] 蔡鸿彦[1] 董芳[1] 刘嵋松[1] 孙良梅[1] 朴铁花[1] 回春[1] 宋智冰[1] 郝毅[1] 王璟琦[1] 李玉春[1] 邱婧[1] 王春兰[1] 张彦峰[1] 王丽[1] 冯潇[1] 席中原[1] 朱玉洁[1] 王芳[1] 王玉[1] 

机构地区：[1]吉林省中医药科学院

出　　处：《中医杂志》2013年第12期1017-1020,共4页Journal of Traditional Chinese Medicine

基　　金：国家科技重大专项资助项目(2008ZX10005-010)

摘　　要：目的评价中药联合化疗方案对初治继发性肺结核的疗效及安全性。方法将1402例来源于全国13家医院的初治继发性肺结核患者随机分为试验组和对照组各701例,对照组采用2HREZ/4HR化疗方案治疗,试验组在化疗方案的基础上肺阴虚证加滋阴润肺免煎颗粒,阴虚火旺证加肺泰胶囊,气阴两虚证加双百口服液,两组疗程为6个月,观察两组痰涂片转阴率、肺部病灶和空洞X线疗效、中医证候疗效及毒副作用发生情况。结果治疗后1个月,两组患者痰菌涂片阴性率比较差异有统计学意义(P<0.05),试验组优于对照组;试验组肺部病灶X线疗效明显吸收及吸收与对照组比较差异有统计学意义(P<0.01);两组患者空洞闭合率比较差异无统计学意义(P>0.05)。两组患者3种中医证型愈显率比较差异均有统计学意义(P<0.01),试验组优于对照组;两组阴虚火旺证总有效率比较差异具有统计学意义(P<0.01)。两组肝功能异常、白细胞减少及胃肠道不良反应比较差异有统计学意义(P<0.05或P<0.01),试验组少于对照组。结论中西医结合治疗方案治疗初治继发性肺结核临床疗效显著,安全可靠。Objective To evaluate the efficacy and safety of Chinese medicine combined with chemotherapy in the initial treatment for secondary pulmonary tuberculosis （TB）. Methods Totally 1 402 cases of secondary pulmonary TB from 13 domestic agencies were randomized into the trial group and control group, with 701 in each. All patients were treated with 2HREZ/4HR chemotherapy program. The trial group was added with Chinese medicine according to the patterns： patients with lung yin deficiency pattern were given Ziyin Runfei Particles （yin-enriching lung-moistening particles）, patients with yin deficiency fire effulgence pattern were given Feitai Capsule and patients with qi-yin deficiency pattern were given Shuangbai Oral Liquid. The sputum smear, blood and liver function were detected monthly. The chest X-ray was reviewed and TCM patterns were scored bimonthly. The treatment course lasted for 6 months. The sputum smear-negative rate, lung shadows absorption, cavity closure, TCM pattern efficacy and side reactions were observed in both groups. Results The sputum smear-negative rate in the trial group was superior to that in the control group after 1-month treatment （P〈0.05）. There was no significant difference between groups in the sputum smear-negative rate after 2-month, 3-month, 4-month, 5-month and 6-month treatment （P〈0.05）. The obvious absorption and absorption in the trial group was superior to that in the control group （P〈0.01）. There was no significant difference between groups in the cavity closure （P〈0.05）. The markedly effective rate of patients with three patterns in the treatment group was superior to that in the control group （P〈0.01）. There was a significant difference between groups in the total effective rate of patients with yin deficiency fire effulgence pattern （P〈0.01）. There was no significant difference between groups in the total effective rate of patients with other two patterns （P〈0.05）. There was a significant difference between groups in the ab

关 键 词：继发性肺结核 中西医结合疗法 肺阴虚证 阴虚火旺证 气阴两虚证 

分 类 号：R521[医药卫生—内科学]