鼻内镜术后塞来昔布镇痛效果临床研究  

Clinical investigation of the analgesic effects of celecoxib on postoperative endoscopic sinus surgery

作　　者：孟祥明[1] 

机构地区：[1]焦作煤业集团中央医院耳鼻喉科,河南焦作454000

出　　处：《中国实用医刊》2013年第12期70-71,共2页Chinese Journal of Practical Medicine

摘　　要：目的探讨鼻内镜术后口服塞来昔布胶囊的镇痛效果。方法选择鼻内镜手术患者100倒，随机分成两组，每组50例。实验组术后口服塞来昔布胶囊0．2g／次，每日2次；对照组术后不服用塞来昔布胶囊。应用视觉模拟评分表分别于术后6、12、24、48h评测患者疼痛程度，观察恶心、呕吐、头晕、嗜睡、皮疹等常见的不良反应。结果实验组术后6、12、24及48h各时点VAS评分均小于对照组，差异有统计学意义（P〈0．05）。常见不良反应发生情况两组比较差异无统计学意义（P〉0．05）。结论鼻内镜术后口服塞来昔布镇痛效果满意，是一种安全、有效、经济、方便的镇痛方法。Objective To investigate the analgesic effect of oral administration of celecoxib capsules on patients with nasal endoscopic surgery. Methods One hundred patients with endoscopic sinus surgery were randomly divided into two groups, each group has 50 patients. Patients in the experiment group were given celecoxib capsules （200 mg every time） after surgery, 2 times a day; Patients in the control group were not given celecoxib. Pain intensity were evaluated by visual analogue scale （VAS） at 6, 12, 24 and 48 hours after operation respectively. Nausea, vomiting, dizziness, drowsiness, skin rashes and other common adverse effects were observed. Results The VAS in the experimental group were lower than that in the control group at the time 6, 12, 24 and 48 hours after surgery（ P 〈0. 05）, there was statistically significant difference （ P 〈 0. 05）. In common adverse reactions, there was not statistically significant difference （ P 〉 0. 05 ）. Conclusions The analgesic effect of oral administration of celecoxib capsules on patients underwent nasal endoscopic surgery is satisfied. It is a safe, effective, economical, convenient method for analgesia.

关 键 词：塞来昔布 镇痛作用 鼻内镜手术 

分 类 号：R765.9[医药卫生—耳鼻咽喉科]