诺氟沙星-Zn^2＋金属分子印迹膜色谱的制备及性能  

Reparation and Properties of the Norfloxacin-Zinc (Ⅱ) Molecularly Imprinted Membrane Chromatography

作　　者：皇甫风云[1] 王兵[2] 孙妍 

机构地区：[1]天津工业大学纺织助剂有限公司 [2]天津工业大学中空纤维膜材料与膜过程省部共建国家重点实验室培育基地,天津工业大学环境与化学工程学院,天津300387

出　　处：《高分子材料科学与工程》2013年第6期129-132,共4页Polymer Materials Science & Engineering

基　　金：天津市自然科学基金重点项目(13JCQNJC02600)

摘　　要：将膜色谱技术和分子印迹技术相结合,制备了诺氟沙星-Zn2+金属分子印迹膜色谱。采用扫描电镜分别观察了聚合物和膜色谱的结构,并考察了不同印迹聚合物填充量对膜色谱的纯水通量和对目标分子的吸附识别能力的影响。结果表明,阶段性升温沉淀聚合制备的印迹聚合物微球粒径均一,适合做膜填充吸附剂。随着填充量的增加可以明显观察到膜内的填充物增加,膜色谱的结构变致密。当填充量为45%(质量分数,下同)、聚偏氟乙烯(PVDF)16%、聚乙二醇(PEG)-400 15%、聚乙烯吡咯烷酮(PVP)3%;铸膜液温度为50℃,凝固浴温度为20℃时制备得到的诺氟沙星-Zn2+金属分子印迹膜色谱的吸附容量为72 mg/g。Combining the advantages of membrane chromatography technology and molecular imprinting technique, the norfloxacin-Zn^2＋ metal molecularly imprinted membrane chromatography was successfully prepared. The structure of the molecular imprinted polymer and membrane chromatography were observed by scanning electron microscopy. The effects of the polymer amount on the performance of the membrane Chromatography were studied by water flux test. The membrane chromatography morphology densification was increased with the addition of the filling polymer. Static binding assay results indicate that with the preparation temperature of 50 ℃ and coagulation bath temperature of 20 ℃, the filling polymer 45%, PVDF 16%, PEG-400 15%, polyvinyl pyrrolidone（PVP） 3%, the prepared molecularly imprinted membrane chromatography displays the high capacity of the target molecule and recognition ability. Maximum adsorption capacity is 72 mg/g.

关 键 词：膜色谱 分子印迹 诺氟沙星 水通量 

分 类 号：O658.64[理学—分析化学]