血清MMP-3和TIMP-1水平在子宫内膜异位症诊断中的意义  

Diagnostic Value of Levels of Serum Matrix Metalloproteinase-3 and Tissue Inhibitor of Matrix Metalloproteinase-1 in Patients with Endometriosis

作　　者：岳庆阳[1] 解芳[2] 张丽红[1] 刘民力[1] 

机构地区：[1]解放军第202医院体检中心,沈阳110003 [2]中国医科大学高等职业技术学院,沈阳110001

出　　处：《临床误诊误治》2013年第6期83-85,共3页Clinical Misdiagnosis & Mistherapy

摘　　要：目的探讨血清基质金属蛋白酶3(matrix metalloproteinase-3,MMP-3)和基质金属蛋白酶组织抑制因子1(tis-sue inhibitor of matrix metalloproteinase-1,TIMP-1)在子宫内膜异位症诊断中的意义。方法选取46例子宫内膜异位症为观察组,40例健康体检女性作为对照组。测定两组血清MMP-3和TIMP-1水平并进行比较。结果血清MMP-3和TIMP-1水平观察组分别为(139.7±71.0)μg/L、(340.8±111.5)μg/L,对照组分别为(70.5±32.0)μg/L、(188.9±72.8)μg/L,两组比较差异均有统计学意义(P<0.01)。患者血清MMP-3和TIMP-1的ROC曲线下面积分别为0.831和0.864,差异有统计学意义(P<0.01),两者联合检测诊断子宫内膜异位症灵敏度为97.4%,特异度为96.3%。相关分析显示,血清TIMP-1与MMP-3水平呈正相关(r=0.5003,P<0.01)。结论 MMP-3和TIMP-1可能与子宫内膜异位症的发生、发展有关,血清MMP-3和TIMP-1检测可作为该病诊断的辅助手段。Objective To evaluate significance of levels of serum matrix metalloproteinase-3 （MMP-3） and tissue inhibitor of matrix metalloproteinase-1 （TIMP-1） in diagnosis of endometriosis. Methods A total of 46 patients with endometriosis （observation group） and 40 healthy women （control group） were recruited in this study. Serum levels of MMP-3 and TIMP-1 in the two groups were measured and compared. Results Serum levels of MMP-3 and TIMP-1 in observation group were （139.7 ±71.0）μg/L and （340.8 ± 111.5 ） μg/L, and （70.5 ± 32.0） μg/L and （ 188.9 ± 72.8 ） μg/L in control group respectively. The differences of the two groups were statistically significant （P 〈 0. 01 ）. Area under receiver operating characteristic （ ROC ） curves of serum MMP-3 and TIMP-1 were 0. 831 and 0. 864 respectively （P 〈0. 01 ）. The sensitivity of combined detection of serum MMP-3 and TIMP-1 was 97.4% , and specificity was 96.3%. Serum levels of TIMP-1 showed positive correlation with MMP-3 （r = 0. 5003, P 〈 0. 01 ）. Condusion MMP-3 and TIMP-1 may be related to the progression of endometriosis, and serum levels of MMP-3 and TIMP-1 may be helpful in diagnosis and adjuvant approaches of endometriosis.

关 键 词：子宫内膜异位症 基质金属蛋白酶3 基质金属蛋白酶组织抑制因子1 

分 类 号：R711.71[医药卫生—妇产科学]