肺表面活性剂联合持续气道正压通气治疗新生儿呼吸窘迫综合征疗效观察  

Analysis of Therapeutic Effect of Calf Pulmonary Surfactant for Injection Combined with Nasal Continuous Positive Airway Pressure on Premature Infants with Respiratory Distress Syndrome

作　　者：葛标[1] 张翔[1] 

机构地区：[1]安徽省阜阳市太和县中医院,安徽阜阳236607

出　　处：《儿科药学杂志》2013年第6期24-26,共3页Journal of Pediatric Pharmacy

摘　　要：目的:观察注射用牛肺表面活性剂(珂立苏)联合鼻塞持续气道正压通气(nCPAP)治疗新生儿呼吸窘迫综合征(NRDS)的疗效。方法:选取2009年6月至2012年6月太和县中医院新生儿科收治的NRDS患儿60例,随机分为治疗组和对照组各30例。治疗组经气管内滴入牛肺表面活性剂后拔管给予nCPAP支持治疗,对照组单纯应用nCPAP支持治疗,比较两组患儿治疗24 h后的疗效及治疗前后的血气分析、X线胸片情况。结果:治疗24 h后,治疗组总有效率86.66%,对照组70.00%,两组比较差异有统计学意义(P<0.05);治疗1 h、12 h、24 h后,治疗组血气分析指标均好于对照组(P均<0.05)。结论:注射用牛肺表面活性剂联合nCPAP治疗NRDS疗效确切,可提高抢救成功率。Objective： To observe the effect of calf pulmonary surfactant for injection combined with nasal continuous positive airway pressure（nCPAP） in the treatment of neonatal respiratory distress syndrome（NRDS）.Methods： Thirty cases in the treatment group were given calf pulmonary surfactant for injection by intratracheal instillation,and then followed by nasal continuous positive airway pressure（nCPAP）.30 cases in the control group were only treated by nCPAP.Clinical effects,blood gas analysis and chest X-ray changes before and after treatment were compared.Results： The clinical effect of the treatment group was better than that of the control group.The total effective rate of the treatment group（86.66%） was significantly higher than that of the control group（70.00%） after treatment for 24 hours（P0.05）.Blood gas analysis result was improved markedly at the time of 1,12,24 hours after treatment in the treatment group;there were significant differences between the two groups（P0.05）.Conclusions： The application of calf pulmonary surfactant for injection combined with nCPAP in the treatment of NRDS has good effects and raises the rescue success rate significantly.

关 键 词：注射用牛肺表面活性剂 鼻塞持续气道正压通气 新生儿 呼吸窘迫综合征 

分 类 号：R722.6[医药卫生—儿科]