硫酸软骨素A介导的恶性疟原虫感染的红细胞粘附  

Adhesion of Plasmodium falciparum-infected red blood cell mediated by chondroitin sulfate A

作　　者：高美丽[1] 王宪锋[2] 杨建雄[1] 

机构地区：[1]陕西师范大学生命科学学院,陕西西安710062 [2]第四军医大学寄生虫学教研室,陕西西安710032

出　　处：《陕西师范大学学报（自然科学版）》2000年第1期96-100,共5页Journal of Shaanxi Normal University：Natural Science Edition

摘　　要：对硫酸软骨素A(chondroitinsulfateA ,CSA)的粘附机制进行了初步探讨 .研究表明 ,恶性疟原虫感染的红细胞可粘附于各种器官的微血管内皮细胞 ,这种粘附被认为是红细胞膜表面分子与内皮细胞表面分子间配体 -受体相互作用的结果 .CSA为内皮细胞表面感染的红细胞 (infectedredbloodcell,IRBC)的粘附受体和恶性疟原虫红细胞膜蛋白Adhesion of Plasmodium falciparum infected red blood cell (IRBC) to microvascular endothelium of various organs,a process known as sequestration,is a feature of Plasmodium falciparum malaria.This event is mediated by specific adhesive interactions between ligands expressed on the surface of IRBC and host receptors. Studies suggested that chondroitin sulfate A (CSA) plays a key role as a receptor in it. Description of the adhesion mechanism of IRBC to CSA could enrich the intercellar adhesion theory, pave the way to more detailed understanding of the pathogenesis of severe malaria and contribute to potential therapeutic strategies targeting the interaction and to the development of an anti sequestration vaccine.Important advances about CSA adhesion in the most recent years are described in this review.

关 键 词：恶性疟原虫 硫酸软骨素A 红细胞膜蛋白 

分 类 号：R382.31[医药卫生—医学寄生虫学]