响应面法设计优化石杉碱甲提取工艺研究  

Optimization of the Extraction Technique of Huperzine A by Response Surface Method

作　　者：张卫刚[1,2] 侯文洁[1] 王涛 秦宝福[1] 

机构地区：[1]西北农林科技大学生命科学学院,陕西杨凌712100 [2]杨凌皓天生物工程技术有限公司,陕西杨凌712100

出　　处：《广东化工》2013年第11期18-20,共3页Guangdong Chemical Industry

摘　　要：利用响应面分析法对千层塔中石杉碱甲的提取工艺进行优化。以乙醇浓度、乙醇倍量及pH为响应因子,石杉碱甲提取得率和纯度为响应值,根据中心组合(BBD)试验设计3因素3水平响应面分析。得出千层塔中石杉碱甲的最佳工艺条件为:乙醇浓度90%,乙醇倍量为7,调pH=9,该条件下石杉碱甲的提取率为89.26%,产品纯度为6.93%。By using response surface methodology to optimize the extraction process of Hup A from Huperzia serrataTrev. Ethanol times, ethanol concentration, and pH is the response factor, Huperzine A extraction yield and purity of the response value, according to the principle of Box-Benhnken experiment, response surface analysis with 3 factors at 3 levels. Huperzine A optimum conditions were as follows： 90 % ethanol concentration, ethanol 7 times, pH=9, under this conditions the huperzine A extraction rate of 89.26 %, purity of product 6.93 %.

关 键 词：石杉碱甲 千层塔 提取 响应面分析 

分 类 号：TQ463.54[化学工程—制药化工]