双黄花颗粒抗炎解热药理作用的实验研究  

Experimental Study of Shuanghuanghua Granule on the Pharmacological Action of Anti-inflammatory and Antipyretic

作　　者：刘林[1] 莫韦皓[1] 邓东方[1] 孟盼[2] 杨蕙[2] 王宇红[2] 

机构地区：[1]湖南中医药大学第一附属医院,湖南长沙410007 [2]湖南中医药大学,湖南长沙410208

出　　处：《中国中医急症》2013年第6期887-888,940,共3页Journal of Emergency in Traditional Chinese Medicine

基　　金：湖南省教育厅科研项目(09C751);湖南省中医药管理局科研项目(2009030)

摘　　要：目的观察双黄花颗粒的抗炎、解热的药理作用。方法采用足肿胀、耳肿胀及毛细血管通透性实验来观察该制剂抗炎作用;采用酵母致大鼠发热实验来观察该制剂解热作用。结果在足肿胀实验中,双黄花高、中剂量组在药后2、4 h均显著抑制角叉菜胶所致大鼠足跖肿胀。此外双黄花高剂量组能显著抑制二甲苯致小鼠耳肿胀的肿胀度及小鼠腹腔毛细血管通透性的增加。在酵母致热实验中,双黄花高剂量组大鼠药后不同时间点体温值显著降低,双黄花中剂量组给药后2 h体温值显著降低。结论双黄花颗粒具有较好的抗炎、解热作用,为其临床应用提供了理论基础。Objective： To study the pharmacologial action and antipyretic effects of Shuanghuanghua Granule with anti-inflammatory.Methods： The anti-inflammatory effects were observed by the rat metatarsal swelling,the mouse auricular swelling and the acetic acid-induced capillary permeability in abdominal cavity in mice experiments.Meanwhile,the antipyretic effect was detected by the fever rat models established by subcutaneous injection of yeast.Results： High and middle does group of Shuanghuanghua Granule significantly reduced the rate of swelling in hind paw after drug 2 and 4 hours.The high does group of Shuanghuanghua Granule obviously decreased mouse ear swelling induced by dimethyl benzene and capillary permeability in abdominal cavity induced by acetic acid-induced.Also,this group of Shuanghuanghua Granule remarkably decreased the body temperature of rats all time.The middle does groups of Shuanghuanghua Granule can significantly decrease the body temperature of rats after drug 2 hours.Conclusion： Shuanghuanghua Granule has obvious anti-inflamation and antipyretic effects.

关 键 词：双黄花颗粒 急性上呼吸道感染 抗炎 解热 

分 类 号：R285.5[医药卫生—中药学]