骨髓增生异常综合征患者p15^(INK4B)基因甲基化与疾病进展的Meta分析  

Effect of p15^(INK4B) Gene Methylation in Myelodysplastic Syndromes' Progressing:A Meta-analysis of Literature

作　　者：张耀[1] 宋陆茜[1] 吴凌云[1] 常春康[1] 李晓[1] 

机构地区：[1]上海交通大学附属第六人民医院血液科,上海200233

出　　处：《肿瘤防治研究》2013年第6期525-530,共6页Cancer Research on Prevention and Treatment

摘　　要：目的分析骨髓增生异常综合征(MDS)患者p15INK4B基因甲基化与疾病进展的关系。方法搜索Cochrane Library、Medline、PubMed、Embase、OVID、Springlink、CBMdisc、VIP、万方和CNKI数据库(1979 to 2012),查找报道MDS患者及sAML(MDS转化的白血病)患者p15INK4B基因甲基化发生率的文献,使用RevMan 5.0对数据进行统计分析。结果共有20篇文献检测了MDS患者p15INK4B基因甲基化状态,并报道了患者骨髓原始细胞数;其中9篇文献包括sAML患者(共690名患者)。p15INK4B基因甲基化状态在骨髓原始细胞5%～19%组中高于原始细胞<5%组(RR=0.41,95%CI:0.33～0.50),sAML组高于MDS原始细胞5%～19%组(RR=0.51,95%CI:0.41～0.64)。4篇文献报道了MDS患者疾病的进展(包括179名患者)。p15INK4B基因甲基化阳性组疾病进展率高于甲基化阴性组(RR=3.09,95%CI:2.04～4.68)。结论 p15INK4B基因甲基化与MDS患者疾病进展及白血病转化密切相关。Objective To determine the relationship between p]5INK4B gene methylation and disease pro- gress in myelodysplastic syndromes（MDS） patients. Methods Literatures from Cochrane Library, Med line, PubMed, Embase, OVID, Springlink , CBMdise, VIP, Wangfang and CNKI databases （ 1979 to 2012） were collected, in which p15INK4B gene methylation in MDS and sAML（MDS transformed leukemi- a） patients were reported, RevMan 5.0 was used for data statistical analysis. Results A total of 20 trials tested p]51NK4B gene methylation status, and reported the number of bone marrow original cells in MDS patients; in which nine literatures included SAML patients （690 patients）. The p]5INK4B gene methylation status in the 5% to 19 original cells group of bone marrow was higher than that in 5 the original cells group （RR = 0. 41, 95CI： 0. 33 to 0. 50）. The gene methylation in SAML groups was higher than that in 50/00 to 19 original cells group （RR = 0. 51, 95%CI： 0. 41 to 0. 64） Data form 4 articles （inclu ding 179 patients） suggested that p15ma4B gene methylation was related to the disease progression of MDS （RR = 3.09,95%CI： 2. 04 to 4. 68）. Conclusion p15K4B gene methylation was associated with disease progress and leukemia transformation.

关 键 词：骨髓增生异常综合征 p15INK4B基因 甲基化 

分 类 号：R551.3[医药卫生—血液循环系统疾病]