小剂量他达那非治疗骨盆骨折后勃起功能障碍的疗效观察  

Low-dose tadalafil for erectile dysfunction following pelvic fracture-induced urethral injury:Clinical observation of 42 cases

作　　者：汤育新[1] 甘宇[1] 张晓波[2] 朱湘生 蒋先镇[1] 何乐业[1] 阳建福[1] 

机构地区：[1]中南大学湘雅三医院泌尿外科,湖南长沙410013 [2]中南大学湘雅医院泌尿外科,湖南长沙410008 [3]湘潭市中心医院男科,湖南湘潭411100

出　　处：《中华男科学杂志》2013年第6期539-541,共3页National Journal of Andrology

摘　　要：目的:评估小剂量他达那非每日给药一次治疗骨盆骨折后勃起功能障碍(ED)的疗效。方法:42例骨盆骨折后ED患者依据外伤后时间分为3组,A组:<1个月组、B组:6～24个月组和C组:>24个月组,每天给予5 mg他达那非连续治疗12周,应用IIEF-5评分和"性活动日志"(SEP)评估疗效。结果:共34例患者完成研究,3组均对骨盆骨折后ED有一定的疗效。A组SEP1、SEP2和SEP5平均阳性回答率分别为70%、59%、52%,均显著高于B、C组(P均<0.05);12周后,3组IIEF-5评分分别增加(3.20±2.62)、(1.31±1.70)、(0.91±1.87)分,A组显著高于B、C组(P均<0.05)。结论:小剂量他达那非每日给药一次对骨盆骨折后ED有较好的康复作用,外伤后越早使用其疗效越好。Objective： To evaluate the efficacy of daily low-dose tadalafil in the treatment of erectile dysfunction （ED） following pelvic fracture-induced urethral injury （PFUI）. Methods： Based on the length of time between pelvic fracture and the patients＇ clinic visit, we divided 42 PFUI-caused ED patients into groups A （ 〈 1 month）, B （ 6 - 24 months） and C （ 〉 24 months）. We treated them with tadalafil at 5 mg daily for 12 weeks consecutively, followed by evaluation of the.therapeutic effect using IIEF-5 questionnaire and Sexual Encounter Profile （SEP） diaries. Results： Thirty-four patients （83.3%） completed the investigation and all responded well to tadalafil medication. Group A showed significant differences from B and C in the increase of IIEF-5 scores and the positive rate of SEP. Conclusion ： Daily low-dose tadalafil helps penile rehabilitation in ED patients following PFUI, and the earlier the medication is initiated, the better the effect will be.

关 键 词：他达那非 勃起功能障碍 阴茎康复 国际勃起功能指数-5 性活动日志 

分 类 号：R698.1[医药卫生—泌尿科学]