聚乙二醇干扰素α-2a联合利巴韦林治疗慢性丙型肝炎7例疗效分析  

Ribavirin combined with interferon for treatment of chronic hepatitis C: a report of 7 cases

作　　者：姚彬[1] 

机构地区：[1]安徽省淮北市人民医院感染病科,235000

出　　处：《蚌埠医学院学报》2013年第5期589-591,共3页Journal of Bengbu Medical College

摘　　要：目的:根据慢性丙型肝炎病毒(HCV)RNA基因型和治疗早期病毒学应答制定干扰素(IFN)联合利巴韦林(RBV)的治疗方案,并探讨其临床疗效。方法:应用基因型特异性引物反转录PCR法检测患者的基因型。基因1型:RBV1.0～1.2 g/d口服,聚乙二醇干扰素α-2a(PEG-IFNα-2a)180μg,皮下注射,每周1次,疗程48周;基因2/3型:RBV 800 mg/d,PEG-IFNα-2a180μg,皮下注射,每周1次,疗程24周。治疗4周、12周及疗程结束24周检测HCV RNA载量,根据4周、12周检测HCVRNA的结果适当调整治疗疗程。结果:7例患者均获得了持续病毒学应答。结论:根据HCV RNA基因型及治疗早期(4周、12周)和24周的病毒学应答制定治疗方案,是一种有效的方法。Objective： To evaluate the therapy of ribavirin（RBV） plus interferon（IFN） which was made according to the genotype of hepatitis C virus（HCV） and virological response for treatment of hepatitis C.Methods： The genotype of 7 patients with chronic hepatitis C was detected by reverse-transcript PCR.The patients with genotype 1 received the therapy of RBV 1.0-1.2 g / d,P.O combined with per week pegylated interferon ɑ-2a（PEG-IFN ɑ-2a） subcutaneous injection,180 μg for 48 weeks,and patients with genotype 2 /3 were treated by RBV（800 mg / d,P.O） combined with per week PEG-IFN ɑ-2a subcutaneous injection,180 μg for 24 weeks.The load of HCV RNA was detected after 4,12 and 24 week during the therapy.The treatment period was modified according to the serum levels of HCV RNA.Results： Sustained virological response was observed in all the 7 patients.Conclusions： Modifying the therapy for patients with chronic hepatitis according to the genotype of HCV and the virological response is of vital importance to enhance the antiviral efficacy.

关 键 词：肝炎 丙型 慢性 干扰素Α 利巴韦林 

分 类 号：R512.63[医药卫生—内科学]