蕲蛇提取物抗炎镇痛药理作用的研究  

Research on Anti-inflammatory and Analgesic Effects of the Agkistrodon acutus extracts

作　　者：蒋福升[1] 马哲龙[1] 陈金印[1] 丁兴红[1] 丁志山[1] 范永升[1] 

机构地区：[1]浙江中医药大学,浙江杭州310053

出　　处：《蛇志》2013年第2期97-99,共3页Journal of Snake

基　　金：浙江省重点创新团队(中医内科临床创新团队)科研基金项目(2011R09042-04;2011R09042-03)

摘　　要：目的研究蕲蛇提取物的抗炎及镇痛作用,为蕲蛇的临床应用提供科学依据。方法采用热板法、冰醋酸刺激致痛法研究蕲蛇提取物对小鼠痛阈的影响,利用二甲苯致小鼠耳廓炎症模型和腹腔染料渗出法测定蕲蛇提取物的抗炎作用。结果蕲蛇提取物醇溶性和水溶性部位对小鼠热板及冰醋酸致痛反应有明显镇痛作用,对二甲苯致小鼠耳廓肿胀、冰醋酸致腹腔毛细血管通透性增高均有明显的抑制作用。结论蕲蛇提取物醇溶性和水溶性部位有一定的抗炎及镇痛作用,并且水溶性部位较醇溶性部位的药效好,可为蕲蛇的临床应用提供指导作用。Objective To research the analgesic effects and anti-inflammatory effect of Agkistrodon acutus ex- tracts. Methods Different animal models were established to observe the anti-inflammatory and analgesic effects of Agkistrodon acutus extracts. The animal models included dimethyl benzene-induced acute ear swelling,increased capillary permeability induced by acetic acid,pain expermients induced by hot plate and glacial acetic acid in mice. Results Water extraction and ethanol extraction of Agkistrodon acutus could relieve the pain caused by glacial acetic acid and by hot plate;it also showed obvious inhibitory effects on the increased capillary permeability induced by glacial acetic acid,and dimethyl benzene-induced ear swelling in mice. Conclusion Water extraction and etha- nol extraction of Agkistrodon acutus showed anti-inflammatory and analgesic effects in the study,and water extrac- tion has a better effect than the ethanol extraction.

关 键 词：蕲蛇 抗炎 镇痛 

分 类 号：R282.7[医药卫生—中药学]