吡啶[3,2-α]咔唑及其类似物的合成  

The Synthesis of Pyrido[3,2-α]carbazole and Their Analogues

作　　者：岳智洲[1] 李波[1] 

机构地区：[1]武汉理工大学化学工程学院制药工程系,湖北武汉430070

出　　处：《安徽化工》2013年第3期37-40,共4页Anhui Chemical Industry

摘　　要：以3-吲哚甲醛及其类似物和3-溴吡啶乙酸乙酯为原料,经过Knoevenagel缩合和Heck反应,得到了一系列的吡啶[3,2-α]咔唑及其类似物,化合物结构经熔点、LC-MS和1H-NMR确证。值得一提的是,这是一种全新的高效的合成吡啶[3,2-α]咔唑及其类似物的方法。The target compounds pyrido [3,2-α]carbazole and their analogues was synthesized from 3-indolecarbaldehyde and ethyl 2-（3-bromopyridin-2-yl） acetate by Knoevenagel condensation and Heck reaction. The structure of the compounds were confirmed by melting point, LC-MS and IH-NMR. It was noteworthy that this procedure provided a new and rapid method to synthesize pyrido[3,2-α]carbazole derivatives and their analogues

关 键 词：KNOEVENAGEL缩合 HECK反应 吡啶[3 2-α]咔唑 

分 类 号：O622.6[理学—有机化学]