新生儿胆红素脑病监测体液免疫功能的意义  

Significance of monitoring the humoral immune function of newborn infants with bilirubin encephalopathy

作　　者：邱建武[1] 肖小兵[1] 刘绍华[1] 刁诗光[1] 冯奔红[1] 刘晓燕[1] 马占忠[2] 

机构地区：[1]汕头大学医学院附属粤北人民医院儿科,广东韶关512026 [2]汕头大学医学院附属粤北人民医院检验科,广东韶关512026

出　　处：《右江医学》2013年第3期332-334,共3页Chinese Youjiang Medical Journal

基　　金：广东省韶关市医药卫生科研计划项目(编号:Y12114)

摘　　要：目的探讨体液免疫功能在新生儿胆红素脑病形成中的意义。方法选择2011年10月至2013年2月粤北人民医院新生儿科收治的重症黄疸足月患儿52例,根据临床表现及头颅MR结果分为胆红素脑病组(观察组)与非胆红素脑病组(对照组),比较两组患儿血清IgG、IgA、IgM补体C3、补体C4的水平。结果两组比较,观察组IgA、IgM水平明显高于对照组(P<0.01),而IgG、补体C3、补体C4差异无统计学意义(P>0.05)。结论 IgA、IgM升高的重度黄疸新生儿更易患胆红素脑病,临床上要注意监测重度黄疸患儿的体液免疫功能。Objective To explore the significance of monitoring the humoral immune function of newborn in- fants with bilirubin encephalopathy. Methods 52 full-term infants with severe jaundice,who were admitted in the de- partment of neonatology of our hospital from October, 2011 to February, 2013, were divided into the bilirubin encepha- lopathy group（the observation group） and the non bilirubin encephalopathy group（control group） according to their clinical manifestation and cranial MRI result. Then,levels of the sera IgG,IgA,alexin C3 and C4 of IgM of these two groups were compared. Results The result showed that the levels of IgA and IgM of the observation group were sig- nificantly higher than that in the control group（ P 〈0.01） ,but no significant differences were found between the two groups in the levels of IgG,alexin C3 and C4（ P〉0.05）. Conclusion Severe jaundice infants with high serum IgA and IgM levels are more open to bilirubin eneephalopathy, so it is necessary to monitor the humoral immune function of newborn infants with severe jaundice clinically.

关 键 词：胆红素脑病 新生儿 体液免疫 

分 类 号：R722.17[医药卫生—儿科]