不同浓度自体骨髓移植治疗骨不连的实验研究  

Experimental study on different concentrations of autologous bone marrow transplantation in the treatment of bone nonunion

作　　者：张哲敏[1] 张延祠[1] 张国磊[1] 刘建宁[1] 

机构地区：[1]河北医科大学第三医院手外科,石家庄市050051

出　　处：《河北医药》2013年第11期1617-1619,共3页Hebei Medical Journal

摘　　要：目的探讨不同浓度自体骨髓移植治疗骨不连的实验研究,为临床自体骨髓移植治疗骨不连提供可靠依据。方法选用健康新西兰白兔36只,制作骨不连模型,将所有实验动物随机分为3组:A组:1∶1骨髓组;B组:1∶2骨髓组;C组:1∶4骨髓组。定期进行X线摄片、骨密度测定及组织学观察等,评价骨折愈合情况及骨痂质量。结果术后2、4、8周X线摄片、骨密度测定及组织学观察等各项指标A、B、C组依次增高。结论自体骨髓移植可以提高骨折愈合速度及质量。骨折愈合的速度及质量与移植骨髓的浓度成正比。Objective To investigate the therapeutic effect of different concentrations of autologous bone marrow transplantation on bone nonunion so as to provide reliable basis for treating bone nonunion in clinic. Methods 36 healthy New Zealand rabbits were selected to make bone nonunion models. All the experimental animals were randomly divided into 3 groups ： group A with 1 ： 1 marrow; group B with 1 ： 2 marrow; group C with 1 ： 4 marrow. The healing state of bone fracture and callus quality were evaluated by regular X-ray examination, bone densitometry and histological observation. Results At 2,4,8 weeks after the operation,the healing state of bone fracture and callus quality were improved in group A, B, C in turn. Conclusion Autologous bone marrow transplantation can enhance healing speed and quality of bone fracture. Healing speed and quality of bone fracture are positively correlated with transplanted bone marrow concentration.

关 键 词：骨不连 骨髓移植 浓度 实验研究 

分 类 号：R274.1[医药卫生—中医骨伤科学]