心室辅助装置部分辅助对羊心脏血流动力学的影响  

Partial support of the ovine heart with left ventricular assist device:implication for hemodynamic

作　　者：李海洋[1] 吴广辉[2] 蔺嫦燕[2] 候晓彤[1] 陈琛 刘修健[2] 徐创业[2] 王璟[2] 杨朋 渠文波 

机构地区：[1]首都医科大学附属北京安贞医院体外循环科,北京100029 [2]首都医科大学附属北京安贞医院心肺血管疾病研究所,北京100029 [3]苏州同心医疗器械有限公司,江苏215125

出　　处：《中国体外循环杂志》2013年第2期103-106,128,共5页Chinese Journal of Extracorporeal Circulation

基　　金：国家高技术研究发展863计划(20012AA041605);首都卫生发展科研专项项目(2011-1005-02)

摘　　要：目的探讨左心室辅助装置在体部分辅助健康实验羊及对羊心脏血流动力学影响。方法实验中,通过心室辅助装置绵羊在体植入辅助实验,辅助装置入口通过不停跳方式植入左心尖,出口与降主动脉吻合。术前以及术后测量羊心输出量、平均动脉压、左房压、左室压(舒张期和收缩期)和心率等血流动力学参数。结果 8例实验动物,5例术后存活超过24 h。实验期间辅助装置没有机械故障发生。实验羊植入心室辅助装置在体部分辅助后,扰乱了羊正常的血液动力学状态,增加了心输出量,降低了心率及左室舒张末期压力,但是平均动脉压、左房压没有显著变化。结论正常实验羊植入心室辅助装置部分辅助支持后,左心室工作量减少,实验动物保持了一个比较正常的心脏血流动力学状态。Objective In Vivo evaluation the hemodynamic changes of the left ventricular assist device assisted normal ovine hearts. Methods In this study, the ventricular assist device was implanted into the left ventricular apex on beating hearts. The out- flow graft of each device was anastomosed to the descending aorta. The left ventricular - stroke volume （ LVSV）, mean arterial blood pressure （MAP）, left atrial pressure （LAP）, left ventricular pressure （LVP） peak diastolic, LVP peak systolic and heart rate （HR） were performed on schedule. Data associated with pump function were collected continuously. Results Five of the 8 animals survived over 24 hours. No thrombus formation or mechanical wearing was observed inside the pump. The partial support of the ovine heart with left ventricular assist device disrupted the normal sheep hemodynamic status, which increased cardiac output, reduced heart rate and left ventricular end - diastolic pressure. But no significant change was observed in mean arterial pressure and left atrial pressure. Con- clusion The partial support of the normal ovine heart with left ventricular assist device can decrease the left ventricular workload; ex- perimental animals can maintain a relatively normal cardiac hemodynamics status.

关 键 词：心室辅助装置 部分辅助 在体实验 血液动力学 

分 类 号：R654.1[医药卫生—外科学]