Comparison between Doppler echocardiography and hot-film anemometry in measuring the turbulent shear stress downstream of artificial mitral valves： a methodological study  

作　　者：SUN Yi LI Rui-jie LI Gan-niu LI Bin WANG Yu MA Run-wei YANG Bai-hui LU Sen-lin ZHANG Gui-min 

机构地区：[1]Department of Cardiovascular Surgery, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650031, China [2]Department of Cardiology , First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650031, China [3]College of Aerospace Engineering, Nanjing University of Aeronauticsand Astronautics, Nanjing, Jiangsu 210016, China

出　　处：《Chinese Medical Journal》2013年第11期2174-2178,共5页中华医学杂志（英文版）

基　　金：This study was supported by grants from the National Natural Science Foundation of China （No. 30860297） and the United Specialized Foundation of Science and Technology Agency of Yunnan Province and Kunming Medical University （No. 2011FB 185）.

摘　　要：Background Turbulent shear stress （TSS） plays an important role in the research of fluid dynamics of heart valves. This study aimed to perform a quantitative study of TSS downstream of porcine artificial mitral valves in order to verify the correlation of hot-film anemometry （HFA） and Doppler echocardiography combined with computer-aided image analysis for the detection of TSS. Methods A porcine model of mitral valve replacement was established. HFA and Doppler ultrasound techniques were used to directly and indirectly measure TSS-relevant parameters of the artificial mitral valve following different mitral valve replacements： different approaches were used to reserve the subvalvular apparatus of the mitral valve. A correlation analysis was then carried out. Results There was a significant correlation between the HFA and Doppler ultrasound combined with computer-aided image analysis of the TSS at the same time and at the same site. No significant difference was found in the TSS measured by the two methods. Conclusions Compared with HFA, Doppler echocardiography combined with computer-aided image analysis is a safe, non-invasive, and real-time method that enables accurate and quantitative detection of TSS downstream in vivo, objectively reflecting the flow field downstream of the artificial mitral valve. Doppler ultrasound combined with computer- aided image analysis can be employed for quantitatively evaluating the downstream hemodynamic performance of the mitral valve.Background Turbulent shear stress （TSS） plays an important role in the research of fluid dynamics of heart valves. This study aimed to perform a quantitative study of TSS downstream of porcine artificial mitral valves in order to verify the correlation of hot-film anemometry （HFA） and Doppler echocardiography combined with computer-aided image analysis for the detection of TSS. Methods A porcine model of mitral valve replacement was established. HFA and Doppler ultrasound techniques were used to directly and indirectly measure TSS-relevant parameters of the artificial mitral valve following different mitral valve replacements： different approaches were used to reserve the subvalvular apparatus of the mitral valve. A correlation analysis was then carried out. Results There was a significant correlation between the HFA and Doppler ultrasound combined with computer-aided image analysis of the TSS at the same time and at the same site. No significant difference was found in the TSS measured by the two methods. Conclusions Compared with HFA, Doppler echocardiography combined with computer-aided image analysis is a safe, non-invasive, and real-time method that enables accurate and quantitative detection of TSS downstream in vivo, objectively reflecting the flow field downstream of the artificial mitral valve. Doppler ultrasound combined with computer- aided image analysis can be employed for quantitatively evaluating the downstream hemodynamic performance of the mitral valve.

关 键 词：PORCINE mitral valve replacement turbulent shear stress Doppler echocardiography hot-film anemometry 

分 类 号：TB126[理学—工程力学] TN911.7[理学—力学]