MR T2~＊成像无创评估多发性硬化患者肝脏铁含量  

MR T2 ＊ imaging assessment of liver iron content in patients with multiple sclerosis

作　　者：黄富洪[1] 李咏梅[1] 吕发金[1] 侯焕新[1] 曾春[1] 王静杰[1] 杜思霖[1] 梦奔[1] 熊华[1] 

机构地区：[1]重庆医科大学附属第一医院放射科,重庆400016

出　　处：《中国医学影像技术》2013年第6期945-948,共4页Chinese Journal of Medical Imaging Technology

基　　金：国家自然科学基金(81171309);重庆市卫生局资助项目(2010-1-004;2011-1-031);重庆市自然科学基金(CSTC2011JJA1073)

摘　　要：目的通过MR T2*技术定量测定多发性硬化(MS)患者肝脏的铁含量,探讨MS患者肝脏铁含量是否与正常人存在差异。方法对35例MS患者(MS组)及17名健康志愿者(对照组)分别进行肝脏T2*扫描,测量肝脏各段的T2*值,并计算其平均值。结合实验室检查检测血清铁、铁蛋白水平,综合评估MS患者机体的铁负载水平。结果 MS组与对照组肝脏平均T2*值分别为17.46±2.82和17.17±3.69(P>0.05)。MS组中9例(9/35,25.71%)、对照组中4例(4/17,23.53%)出现铁过载,但均在可接受范围内(5.0～15.8ms),两组铁过载发病率差异无统计学意义(χ2=0.029,P>0.05)。MS组与对照组血清铁、铁蛋白水平差异均无统计学意义(P均>0.05)。MS组及对照组的T2*值与铁蛋白水平均呈负相关(r=-0.448,P=0.032;r=-0.742,P=0.009),与血清铁未见相关性(P均>0.05)。结论 MS患者机体中的铁负载水平与健康志愿者无明显差异,提示MS患者脑内过度的铁沉积并非由整个机体的铁过载引起。Objective To quantitatively measure the liver iron content in patients with multiple sclerosis （MS） by MR T2＊ mapping, and to explore the differences of liver iron content between MS patients and healthy subjects. Methods Thirty-five MS patients （MS group） and 17 healthy volunteers （control group） underwent MR T2＊ map scanning of the liver. The values of T2＊ in each liver segment were measured, and the mean values were calculated. Then the iron load levels of MS patients were comprehensively assessed, combined with the serum iron and ferritin levels. Results The mean T2＊ values of liver in MS group and control group was 17. 46±2.82 and 17.17±3.69 （P〉0.05）. Nine patients （9/35, 25.71%） in MS group and 4 patients （4/17, 23.53%） in control group were iron overload, however, all were in the acceptable range （5.0-15.8 ms）. The incidence of iron overload between the two groups showed no statistical difference （X2 =0. 029, P〉0.05）. There was no statistical differences between MS group and control group in serum iron and ferritin levels （both P〉0.05）. The values of T2＊ were negatively correlated with ferritin （MS group： r= -0. 448, P=0. 032; control group： r=-0. 742, P=0. 009）, but didn＇t correlate with serum iron （both P〉0.05）. Conclusion No significant difference of iron load was found between MS group and control group, indicating that the excessive iron deposition in MS brain is not caused by iron overload in the entire body.

关 键 词：多发性硬化 磁共振成像 T2＊ 肝脏 血清铁 

分 类 号：R445.2[医药卫生—影像医学与核医学] R744.51[医药卫生—诊断学]