哌仑西平对兔心肌梗死心率变异性、压力反射敏感性与心肌电生理特性的影响  

Effect of Pirenzepine on Heart Rate Variability, Baroreflex Sensitivity and Cardiac Electrophysiologic Characteristics in Rabbits After Myocardial Infarction

作　　者：张燕[1] 张旭明[1] 伍卫[1] 聂如琼[1] 方昶[1] 周淑娴[1] 陈筱潮[1] 

机构地区：[1]中山医科大学孙逸仙纪念医院心内科,广东广州510120

出　　处：《中山医科大学学报》2000年第5期349-351,383,共4页Academic Journal of Sun Yat-sen University of Medical Sciences

基　　金：广州市科委重点科技攻关项目!资助 (97-Z -4 8)

摘　　要：【目的】观察哌仑西平对兔心肌梗死 (MI)后心率变异性 (HRV)、压力反射敏感性 (BRS)和心肌电生理特性的影响。【方法】 36只兔随机分为对照组、心肌梗死组和哌仑西平组 ,2周后测量HRV、BRS、心室有效不应期离散性 (VERP D)和室颤阈值 (VFT)。各指标间进行相关性分析。【结果】心肌梗死后HRV各指标和BRS明显降低 ,VERP D明显增加 ,VFT降低。哌仑西平明显增加心肌梗死后HRV各指标和BRS ,减小VERP D ,增加VFT。HRV、BRS与VERP D、VFT有明显的相关性。【结论】哌仑西平增加心肌梗死后迷走神经活性 ,增加心肌电稳定性。哌仑西平增加心脏迷走神经活性 ,可能是其抗心室颤动的机制之一。Objective To study the influences of pirenzepine on heart rate variability, baroreflex sensitivity and cardiac electrophysiologic characteristics in rabbits after myocardial infarction. Methods Thirty-six rabbits were divided into three groups at random: the control group, the myocardial infarction group and the pirenzepine group. After two weeks, following parameters were measured: heart rate variability (HRV), baroreflex sensitivity(BRS), a dispersion of ventricular effective refractory period(VERP-D) and ventricular fibrillation threshold(VFT). Correlation was analyzed among these parameters. Results After myocardial infarction, HRV and BRS were decreased, VERP-D was increased, and VFT was decreased. In comparison with myocardial infarction group, HRV, BRS and VFT were increased and VERP-D was decreased in pirenzepine group. HRV and BRS had significantly correlation with VERP-D and VFT. Conclusion Pirenzepine has the effect of increasing parasympathetic activity and ventricular electric stability , so, it might prevent ventricular fibrillation after myocardial infarction.

关 键 词：心肌梗死 哌仑西平 药理学 电生理学 收率变异性 

分 类 号：R542.220.5[医药卫生—心血管疾病]