阿尔茨海默病与Wnt信号通路及神经干细胞的关系  

Correlation of Alzheimer’s disease with Wnt signaling pathway and neural stem cells

作　　者：王薇[1] 张海廷[1] 王淑辉[1] 张拥波[1] 

机构地区：[1]首都医科大学附属北京友谊医院神经内科,北京市100050

出　　处：《中国组织工程研究》2013年第19期3566-3572,共7页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金(81100237);北京市卫生系统高层次卫生技术人才培养计划项目资助(2009-3-07);北京友谊医院院内启动课题~~

摘　　要：背景:阿尔茨海默病的病因涉及遗传、环境、免疫等多种因素和机制,大量研究表明Wnt信号通路与之密切相关,也有研究表明,Wnt信号通路对神经干细胞的增殖发挥着决定性作用。目的:对阿尔茨海默病的病理过程与Wnt信号通路的关系以及Wnt信号通路与神经干细胞增殖分化进行综述,为阿尔茨海默病的治疗提供理论依据。方法:通过Pubmed数据库检索有关阿尔茨海默病病理过程与Wnt信号通路及Wnt信号通路与神经干细胞关联的相关文献,检索词为"Alzheimer's disease、Wnt signaling pathway、NSCs、stem celldifferentiation、amyloid-βprotein、Protein Tau"。纳入与阿尔茨海默病和Wnt信号通路相关的文献,排除重复性研究,保留50篇文献进行综述。结果与结论:目前通过神经干细胞移植来治疗以神经元的缺失为特征的神经退行性疾病已成为研究的热点,而如何调控神经干细胞向特定神经元分化成为了研究的难点,信号转导在神经干细胞的分化中起重要的作用,其中Wnt信号通路是调节神经干细胞增殖及分化的细胞外的重要因素。Wnt信号通路的失活可以促进阿尔茨海默病的病理过程,相反激活Wnt信号通路可以保护海马神经元,同时促进神经干细胞的分化,为阿尔茨海默病的治疗提供新的思路。BACKGROUND：The pathological mechanism of Alzheimer＇s disease involves inherited, environmental and immunological factors. Strong evidence exists that Wnt signaling pathway is closely related to the pathological process of Alzheimer＇s disease. There is also evidence that Wnt signaling pathway plays a crucial effect on the proliferation of neural stem cel s. OBJECTIVE：To review the relationship between pathological process of Alzheimer＇s disease and Wnt signaling pathway and effects of Wnt signaling on proliferation and differentiation of neural stem cel s, providing theoretical evidence for treatment of Alzheimer＇s disease. METHODS：A computer-based online search of PubMed databases was undertaken for papers addressing the relationship of Alzheimer＇s disease and Wnt signaling pathway and the correlation between Wnt signaling pathway and neural stem cel s using the key words＂Alzheimer＇s disease, Wnt signaling pathway, NSCs, stem cel differentiation, amyloid-βprotein, protein Tau＂. After excluding papers with repetitive contents, 50 papers were suitable for final analysis. RESULTS AND CONCLUSION：Treatment of neurodegenerative diseases characterized by neuron loss using neural stem cel transplantation has become a gradual y increased research area. However, how to regulate neural stem cel s to differentiate into specific neurons has been proposed. Signal transduction plays an important role in the differentiation of neural stem cel s and Wnt signaling pathway is an important extracel ular factor of regulating the proliferation and differentiation of neural stem cel s. Inactivation of Wnt signaling pathway promotes the progression of Alzheimer＇s disease, and activation of Wnt signaling pathway protects hippocampal neurons and promotes the differentiation of neural stem cel s. This may provide novel therapeutic methods for Alzheimer＇s disease.

关 键 词：干细胞 干细胞学术探讨 神经干细胞 阿尔茨海默病 WNT信号通路 痴呆 干细胞移植 β淀粉样蛋白 tau蛋白 糖原合成酶激酶3Β 海马 国家自然科学基金 

分 类 号：R318[医药卫生—生物医学工程]