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机构地区:[1]武警后勤学院附属医院中医康复理疗科,天津市300162 [2]天津中医药大学第一附属医院,天津市300192
出 处:《中国组织工程研究》2013年第19期3573-3580,共8页Chinese Journal of Tissue Engineering Research
摘 要:背景:虽然各种神经退行性疾病的人群发病率居高不下且有上升趋势,但至今仍无有效治疗方法,因此,寻求有效的治疗神经退行性疾病的途径是科学界面临的挑战。目的:文章分析和综述了对干细胞治疗神经退行性疾病的近年研究进展及热点问题。方法:文章对干细胞移植治疗神经退行性疾病,如阿尔茨海默病、帕金森病、脑卒中、亨廷顿病、视网膜色素变性疾病、肌萎缩性侧索硬化症、癫痫等疾病的基础与临床研究进展进行概述,探讨干细胞治疗神经退行性疾病的可行性、优势及问题。结果与结论:干细胞治疗神经退行性疾病大部分研究还是集中在实验动物模型阶段,还没有支持干细胞临床治疗的有效证据,其安全性和有效性还没有确切临床保证和标准,临床治疗效果及不良反应都有待大宗及长期临床试验研究进一步验证。BACKGROUND:Although the incidence of neurodegenerative diseases in various populations is high and has an upward trend, so far there is no effective treatment method. So it is a chal enge for scientific community to seek effective treatment method for the treatment of neurodegenerative diseases. OBJECTIVE:To analyze and review the research progress and hot issues of stem cel s for the treatment of neurodegenerative diseases. METHODS:The basic and clinical researches on stem cel s for the treatment of neurodegenerative diseases were overviewed, including Alzheimer's disease, Parkinson's disease, stroke, Huntington's disease, retinitis pigmentosa, amyotrophic lateral sclerosis and epilepsy, in order to investigate the feasibility, advantages and problems of stem cel s in the treatment of neurodegenerative diseases. RESULTS AND CONCLUSION:Most of the studies on stem cel s in the treatment of neurodegenerative diseases are in the stage of experimental animal models, and there is no valid evidence to support stem cel therapy. There is no exact clinical assurance and standards on the safety and efficacy of stem cel s for the treatment of neurodegenerative diseases, and the clinical efficacy and adverse reactions need to be further verified with large-sample long-term clinical trials.
关 键 词:干细胞 干细胞学术探讨 干细胞移植 神经干细胞 中枢神经系统 神经退行性疾病 阿尔茨海默病 帕金森病 脑卒中 亨廷顿病 视网膜变性疾病 肌萎缩性侧索硬化症 癫痫 临床研究
分 类 号:R318[医药卫生—生物医学工程]
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