白细胞介素-5、可溶性白细胞介素-2受体及一氧化氮与哮喘发病的关系  

Relationship between IL-5, sIL-2R, No and onset of asthma

作　　者：刘锦铭[1] 李秀忠[1] 杨宝珍[1] 许德风[1] 郑西卫[1] 吴振裘[1] 周娅[2] 

机构地区：[1]宁夏医学院附属医院呼吸内科,银川750004 [2]宁夏医学院微生物教研室

出　　处：《临床内科杂志》2000年第5期280-281,共2页Journal of Clinical Internal Medicine

摘　　要：目的探讨白细胞介素－5（IL－5）、可溶性白细胞介素－2受体（sIL－2R）、一氧化氮（NO）及嗜酸性粒细胞（EOS）在哮喘发病中的意义。方法对治疗前后的急性发作期、稳定期哮喘组及对照组血清IL－5、sIL－2R和NO水平及EOS计数进行了研究。结果哮喘急性发作组血清IL-5、sIL－2R、NO及EOS水平均明显高于哮喘缓解期组与对照组。哮喘发作期IL－5与EOS呈显著正相关。哮喘息性发作期组治疗后sIL－2R及NO水平较治疗前显著降低，IL－5与EOS水平下降但无统计学意义。结论血清IL－5、sIL－2R、NO及EOS水平升高，与哮喘发作密切相关。Objective To evaluate the relationship between IL-5, slL-2R, NO and onset ofasthma. Methods The serum levels of IL-5, sIL-2R, NO and EOS count were determined in pa-tients at acute and stable stage before and after treatment, being compared with normal controls.Results The levels of IL-5,slL-2R. NO and EOS in patients at acute stage were significantly higherthan those in patients at stable stage and controls. At acute stage. IL-5 was positively related to EOS.The serum levels of sIL-2R and NO in patients at acute stage obviously decreased after treatment, butthe level of IL-5 and EOS didn'reach the significant decline. Conclusion Increase of IL-5, sIL-2R.NO and EOS levels are closelv related to onset of asthma.

关 键 词：哮喘 白细胞介素5 嗜酸性粒细胞 SIL-2R NO 

分 类 号：R562.25[医药卫生—呼吸系统]