Strength and fatigue properties of three-step sintered dense nanocrystal hydroxyapatite bioceramics  

作　　者：Wen-Guang GUO Zhi-Ye QIU Han CUI Chang-Ming WANG Xiao-Jun ZHANG In-Seop LEE Yu-Qi DONG Fu-Zhai CUI 

机构地区：[1]School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China [2]Beijing AIIgens Medical Science and Technology Co., Ltd., Beijing 100085, China [3]Institute of Natural Science and Atomic-scale Surface Science Research Center, Yonsei University, Seoul 120-749, Korea [4]Department of Orthopedics, Renji Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China

出　　处：《Frontiers of Materials Science》2013年第2期190-195,共6页材料学前沿（英文版）

摘　　要：Dense hydroxyapatite （HA） ceramic is a promising material for hard tissue repair due to its unique physical properties and biologic properties. However, the brittleness and low compressive strength of traditional HA ceramics limited their applications, because previous sintering methods produced HA ceramics with crystal sizes greater than nanometer range. In this study, nano-sized HA powder was employed to fabricate dense nanocrystal HA ceramic by high pressure molding, and followed by a three-step sintering process. The phase composition, microstructure, crystal dimension and crystal shape of the sintered ceramic were examined by X-ray diffraction （XRD） and scanning electron microscopy （SEM）. Mechanical properties of the HA ceramic were tested, and cytocompatibility was evaluated. The phase of the sintered ceramic was pure HA, and the crystal size was about 200 nm. The compressive strength and elastic modulus of the HA ceramic were comparable to human cortical bone, especially the good fatigue strength overcame brittleness of traditional sintered HA ceramics. Cell attachment experiment also demonstrated that the ceramics had a good cytocompatibility.Dense hydroxyapatite （HA） ceramic is a promising material for hard tissue repair due to its unique physical properties and biologic properties. However, the brittleness and low compressive strength of traditional HA ceramics limited their applications, because previous sintering methods produced HA ceramics with crystal sizes greater than nanometer range. In this study, nano-sized HA powder was employed to fabricate dense nanocrystal HA ceramic by high pressure molding, and followed by a three-step sintering process. The phase composition, microstructure, crystal dimension and crystal shape of the sintered ceramic were examined by X-ray diffraction （XRD） and scanning electron microscopy （SEM）. Mechanical properties of the HA ceramic were tested, and cytocompatibility was evaluated. The phase of the sintered ceramic was pure HA, and the crystal size was about 200 nm. The compressive strength and elastic modulus of the HA ceramic were comparable to human cortical bone, especially the good fatigue strength overcame brittleness of traditional sintered HA ceramics. Cell attachment experiment also demonstrated that the ceramics had a good cytocompatibility.

关 键 词：nanocrystal hydroxyapatite ceramic three-step sintering MECHANICALPROPERTY fatigue strength cytocom patibility 

分 类 号：TQ174.759[化学工程—陶瓷工业] TQ174.758[化学工程—硅酸盐工业]