链脲佐菌素糖尿病大鼠肝脏超微结构的变化  

Ultrastructural change of liver in diabetic rats induced by strepotozotocin

作　　者：金英锦[1] 金奎龙[1] 赵正林[1] 朱永哲[1] 

机构地区：[1]延边大学医学院电子显微镜教研室,吉林延吉133000

出　　处：《延边大学医学学报》2000年第1期8-10,共3页Journal of Medical Science Yanbian University

摘　　要：[ 目的 ]为探讨糖尿病引起的肝损害 ,用链脲佐菌素所致糖尿病大鼠观察了超微结构的变化 .[方法 ]将链脲佐菌素注入到大鼠腹腔内 ,测空腹血糖大于 11.1mmol/L者作为糖尿病大鼠模型 .[结果 ]链脲佐菌素糖尿病大鼠的肝细胞、线粒体肿胀 ,空泡样变形 ,嵴断裂 ,糖原颗粒和粗面内质网减少 ,有较多的脂肪滴 ,细胞核有空泡样变化 .[结论OBJECTIVE The ultrastructural change of liver was observed in diabetic rats induced by strepotozotocin in order to study the liver injury caused by diabetes. METHODS Strepotozotocin was injected into the abdominal cavity and fasting blood glucose was measured.The rats whose values were over 11.1mmol/L were chosen as the diabetic models. RESULTS Swelling,vacuolar degeneration and cristae brearing in the mitochondria, reduction of glycogen granules and rough endoplaemic reticulum,fat drops and vacuolar degeneration in the caryons were seen in the liver cells of diabetic rats induced by strepotozotocin. CONCLUSION There was injury to a certain extent in the liver cells of experimental diabetic rats.

关 键 词：链脲佐菌素糖尿病 肝脏 超微结构 肝损伤 

分 类 号：R587.1[医药卫生—内分泌] R575[医药卫生—内科学]