新藤黄酸纳米脂质载体制备及其药剂学性质研究  

Preparation of gambogenic acid loaded nanostructured lipid carriers and its pharmaceutical properties

作　　者：黄霞[1,2] 朱婷婷[1,2] 罗晴[1,2] 王强[3] 龚菊梅[1,2] 陈卫东[1,2] 

机构地区：[1]安徽中医学院临床药学教研室,安徽合肥230038 [2]安徽省高等学校省级现代中药重点实验室,安徽合肥230038 [3]安徽中医学院药学院,安徽合肥230038

出　　处：《中草药》2013年第11期1400-1406,共7页Chinese Traditional and Herbal Drugs

基　　金：国家"重大新药创制"科技重大专项(2009ZX09103-399);安徽省高校省级自然科学研究重点项目(KJ2011A190)

摘　　要：目的制备新藤黄酸纳米结构脂质载体并表征其药剂学性质。方法采用乳化蒸发-低温固化法制备新藤黄酸纳米脂质载体(GNA-NLC),正交试验设计优化最佳工艺处方,并对其包封率、平均粒径及Zeta电位等性质进行考察。结果优化后处方制备的GNA-NLC多为圆整、实体的类球形,平均粒径为(144.07±1.44)nm,多分散系数为0.24±0.01,Zeta电位为(28.03±0.29)mV,包封率为(84.65±0.98)%,载药量为(4.21±0.05)%;DSC显示GNA纳米粒确已形成,并且GNA以非晶态分布在基质中。结论乳化蒸发-低温固化法能成功制备GNA-NLC,工艺简单,易于控制。Objective To prepare and characterize gambogenic acid loaded nanostuctured lipid carrier （GNA-NLC）. Methods GNA-NLC was prepared by emulsion evaporation-low temperature solidification method, and its optimal prescription was selected by orthogonal test design. The characteristics, such as encapsulation efficiency （EE）, average diameter, and Zeta potential, were studied. Results GNA-NLC had a spherical shape with smooth surface with the average diameter of （144.07 ± 1.44） nm, polydispersity index （PI） of 0.24± 0.01, Zeta potential of （-28.03± 0.29）mV. The EE and drug loading were （84.65v 0.98）% and （4.21± 0.05）%, respectively. DSC indicated that GNA was dispersed as non-crystalline in matrix. Conclusion Emulsion evaporation-low temperature solidification method is easy, simple, and feasible to prepare GNA-NLC.

关 键 词：新藤黄酸 纳米脂质载体 微柱离心法 乳化蒸发-低温固化法 正交试验设计 

分 类 号：R283.6[医药卫生—中药学]